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首页> 外文期刊>European journal of gastroenterology and hepatology >Prevalence of hepatitis C infection and risk factors in hospitalized diabetic patients: results of a cross-sectional study.
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Prevalence of hepatitis C infection and risk factors in hospitalized diabetic patients: results of a cross-sectional study.

机译：住院糖尿病患者的丙型肝炎感染率和危险因素：一项横断面研究的结果。

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OBJECTIVES: Although there may exist a nosocomial risk of hepatitis C virus (HCV) infection in patients with type 1 or type 2 diabetes, this risk has not been fully investigated thus far and its magnitude is unknown. The aim of this multicenter cross-sectional study was to evaluate the prevalence of, and risk factors for, hepatitis C infection in consecutive hospitalized patients with diabetes and to assess the nosocomial risk and magnitude of HCV infection in these patients. PATIENTS AND METHODS: Consecutive hospitalized patients with diabetes seen in 11 French hepatogastroenterology and diabetology departments were studied. The prevalence of anti-HCV antibodies was compared with that observed in healthy blood donors and individuals seen during routine medical checkup. Diabetic patients with anti-HCV antibodies were compared with patients without anti-HCV antibodies for assessment of risk factors. RESULTS: In total 1561 patients were studied. Independent risk factors for HCV infection were assessed through multivariate analysis. Thirty-three patients (2.11%) had anti-HCV antibodies and 21 (63.70%) had HCV identified risk factors. The prevalence of HCV infection was higher in patients with diabetes than in blood donors (0.08%) or healthy controls (0.20%) (P<0.001). Multivariate analysis identified four independent risk factors for HCV infection: blood transfusion before 1991 [odds ratio (OR)=2.88, P=0.033], intravenous drug use (OR=21.37, P=0.012), treatment in a hepatogastroenterology center (OR=4.17, P=0.002) and a high number (>2) of previous admissions since the onset of diabetes (OR=2.52, P=0.039). CONCLUSION: A nosocomial source of HCV infection in hospitalized diabetic patients is suggested by the increased risk of HCV infection associated with the number of hospitalizations. This may account for at least 36% of cases of HCV infection.
机译：目的：尽管在1型或2型糖尿病患者中可能存在院内感染丙型肝炎病毒（HCV）的风险，但该风险迄今尚未得到充分调查，其程度尚不清楚。这项多中心横断面研究的目的是评估连续住院的糖尿病患者丙型肝炎感染的患病率和危险因素，并评估这些患者的医院内风险和HCV感染的程度。患者和方法：对法国11所胃肠病和糖尿病科连续住院的糖尿病患者进行了研究。将抗HCV抗体的患病率与健康献血者和常规体检中观察到的个体中的患病率进行了比较。将具有抗HCV抗体的糖尿病患者与未抗HCV抗体的患者进行比较，以评估危险因素。结果：总共研究了1561例患者。 HCV感染的独立危险因素通过多变量分析进行了评估。 33例（2.11％）患者具有抗HCV抗体，21例（63.70％）患者具有HCV识别的危险因素。糖尿病患者的HCV感染率高于献血者（0.08％）或健康对照者（0.20％）（P <0.001）。多变量分析确定了HCV感染的四个独立危险因素：1991年之前的输血[几率（OR）= 2.88，P = 0.033]，静脉吸毒（OR = 21.37，P = 0.012），肝消化病中心的治疗（OR = 4.17，P = 0.002）和自糖尿病发作以来的高入院率（> 2）（OR = 2.52，P = 0.039）。结论：住院患者中HCV感染的医院来源是因住院次数增加而引起的HCV感染风险增加。这可能至少占HCV感染病例的36％。

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