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首页> 外文期刊>European journal of gastroenterology and hepatology >Levofloxacin based regimens for the eradication of Helicobacter pylori.
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Levofloxacin based regimens for the eradication of Helicobacter pylori.

机译：基于左氧氟沙星的方案可根除幽门螺杆菌。

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BACKGROUND: A 7 day treatment scheme based on rabeprazole/levofloxacin/amoxycillin or tinidazole achieved an eradication rate over 90%. However, the combination of drugs and duration of treatment for the correct use of levofloxacin in the eradication of are still unclear. OBJECTIVE: To compare the efficacy and tolerability of rabeprazole/levofloxacin based dual therapies given for 5, 7 or 10 days with rabeprazole/levofloxacin/amoxycillin triple therapy for 7 days. METHODS: One hundred and sixty patients with infection documented by the C-urea breath test and histology were included in this prospective, open label study. Subjects were randomized in four groups: (1) levofloxacin (500 mg o.d.), amoxycillin (1 g b.d.) and rabeprazole (20 mg o.d.) for 7 days; (2) levofloxacin (500 mg o.d.) and rabeprazole (20 mg o.d.) for 5 days; (3) levofloxacin (500 mg o.d.) and rabeprazole (20 mg o.d.) for 7 days; and (4) levofloxacin (500 mg o.d.) and rabeprazole (20 mg o.d.) for 10 days. Six weeks after the end of therapy status was checked by using the C-urea breath test. RESULTS: All patients completed the therapeutic regimens. The eradication rate was not significantly modified by treatment duration in the dual therapy schemes (5 days: 20/40, 50%; 7 days: 28/40, 70%; 10 days: 26/40, 65%). The eradication rate of the 1 week levofloxacin based triple therapy was significantly higher than that observed using any dual therapies (36/40). No major adverse effects were observed. CONCLUSIONS: A rabeprazole/levofloxacin dual eradication regimen is simple and well tolerated but does not achieve an acceptable eradication rate when compared to a 1 week rabeprazole/levofloxacin/amoxycillin triple therapy. The eradication rate did not increase with a longer regimen.
机译：背景：基于雷贝拉唑/左氧氟沙星/阿莫西林或替硝唑的7天治疗方案根除率超过90％。但是，对于根除左氧氟沙星是否正确使用药物和治疗时间尚不清楚。目的：比较以雷贝拉唑/左氧氟沙星为基础的5、7或10天双重疗法与雷贝拉唑/左氧氟沙星/阿莫西林三联疗法为7天的疗效和耐受性。方法：这项前瞻性开放标签研究纳入了C-尿素呼气试验和组织学证明的160例感染患者。将受试者随机分为四组：（1）左氧氟沙星（每日剂量500 mg），阿莫西林（每日剂量1 g）和雷贝拉唑（每日剂量20 mg）;共7天; （2）左氧氟沙星（每日500 mg）和雷贝拉唑（每日20 mg）5天; （3）左氧氟沙星（每日剂量500毫克）和雷贝拉唑（每日剂量20毫克），共7天; （4）左氧氟沙星（每日剂量500毫克）和雷贝拉唑（每日剂量20毫克），治疗10天。治疗结束六周后，通过C-尿素呼气试验检查其状态。结果：所有患者均完成了治疗方案。双重治疗方案中的治疗持续时间对根除率没有显着影响（5天：20 / 40，50％; 7天：28 / 40，70％; 10天：26 / 40，65％）。基于左氧氟沙星的1周三联疗法的根除率显着高于使用任何双重疗法观察到的根除率（36/40）。没有观察到重大不良反应。结论：雷贝拉唑/左氧氟沙星双重根除方案简单，耐受性好，但是与1周雷贝拉唑/左氧氟沙星/阿莫西林三联疗法相比，不能达到可接受的根除率。更长的疗程根除率没有增加。

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