• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>European journal of gastroenterology and hepatology >Immunoglobulin E production in chronic pancreatitis.
【24h】

Immunoglobulin E production in chronic pancreatitis.

机译：慢性胰腺炎中免疫球蛋白E的产生。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

OBJECTIVES Serum immunoglobulin E (IgE) was investigated in patients with chronic pancreatitis in order to elucidate possible disease mechanisms linking pancreatitis, adverse reaction to foods and allergy.DESIGN AND METHODS Serum IgE was analysed in 86 non-atopic patients with advanced chronic pancreatitis and 54 non-atopic controls. IgE detection was performed by enzyme-linked immunofluorescence. RESULTS Mean IgE levels (+/- standard error of mean) in chronic pancreatitis patients (286.1 +/- 49 kU/l) were found to be significantly elevated compared to controls (67.7 +/- 11 kU/l; P < 0.0001). Normal IgE levels (< 100 kU/l) were present in 40/54 control patients (74.1%), but only 39/86 pancreatitis patients (45.3%). Of the patients with chronic pancreatitis, 47/86 (54.6%) had clearly elevated IgE levels of > 100 kU/l and their IgE values did not show a Gaussian distribution. However, nine-fold higher IgE levels were found in chronic pancreatitis patients with alcohol consumption of > 25 g/day and exocrine insufficiency (915.5 +/- 240 kU/l) than in pancreatitis patients with normal exocrine function and no alcohol consumption (103.4 +/- 43 kU/l; P < 0.001). Moreover, acute episodes of chronic pancreatitis were found to increase serum IgE levels.CONCLUSIONS In patients with chronic pancreatitis, serum IgE production is markedly enhanced, especially during acute inflammatory episodes or when alcohol is consumed. Since abstinence from alcohol and pancreatic enzyme substitution are associated with clearly lower IgE levels, it may be concluded that pancreatic insufficiency with reduced nutrient digestion and alcohol consumption stimulate IgE production. This finding gives rise to the speculation that, apart from pancreatic inflammation, cross-linking of IgE with alimentary or other antigens might be involved in the pathophysiology of a sub-population of patients with chronic pancreatitis and manifest pancreatic insufficiency.
机译：目的研究慢性胰腺炎患者的血清免疫球蛋白E（IgE），以阐明与胰腺炎，食物不良反应和过敏相关的可能疾病机制。设计与方法对86例非特应性慢性胰腺炎和54例非特应性患者进行了血清IgE分析。非特应性对照。通过酶联免疫荧光进行IgE检测。结果发现慢性胰腺炎患者的平均IgE水平（平均值的+/-标准误）（286.1 +/- 49 kU / l）与对照组相比（67.7 +/- 11 kU / l; P <0.0001） 。在40/54例对照患者（74.1％）中存在正常的IgE水平（<100 kU / l），但只有39/86例胰腺炎患者（45.3％）。在患有慢性胰腺炎的患者中，47/86（54.6％）的IgE水平明显升高> 100 kU / l，其IgE值未显示高斯分布。但是，发现慢性酒精性肝炎患者中，每天饮酒量> 25 g /天且外分泌功能不全（915.5 +/- 240 kU / l）的IgE水平要比正常外分泌功能且不饮酒的胰腺炎患者高10倍（103.4） +/- 43 kU / l; P <0.001）。此外，发现慢性胰腺炎的急性发作会增加血清IgE水平。结论在慢性胰腺炎患者中，血清IgE的产生显着增加，尤其是在急性炎症发作或饮酒时。由于戒酒和胰酶替代与明显降低的IgE水平相关，因此可以得出结论，营养不足和酒精消耗减少的胰腺功能不全会刺激IgE的产生。这一发现引起了这样的推测，即除了胰腺炎症外，IgE与消化性或其他抗原的交联可能与慢性胰腺炎并表现为胰腺功能不全的患者亚群的病理生理有关。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号