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首页> 外文期刊>European journal of gynaecological oncology >Decreased expression of SIRT6 promotes tumor cell growth correlates closely with poor prognosis of ovarian cancer
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Decreased expression of SIRT6 promotes tumor cell growth correlates closely with poor prognosis of ovarian cancer

机译：SIRT6表达降低促进肿瘤细胞生长与卵巢癌预后不良密切相关

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Introduction: Cancer is a group of diseases characterized by uncontrolled growth and spread of abnormal cells. If the spread is not controlled, it can result in death. Sirtunins belong to a protein family and it is present in all organisms. SIRT6 is downregulated in tumor and acts as tumor suppressor. These sirtunin proteins are linked to repair DNA and metabolism. Material and Methods: To measure the role of SIRT6 in tumor cell, 20 mice were used and European Collection of Cell Cultures (ECACC) cell lines were used for the analysis. A histopathological technique showed the level of tumor cells. Results: A recent study provided exceptional insight into the mechanism of SIRT6-related chromatin regulation. According to the histopathology of cancer, SIRT1 localizes to the promoters of several aberrantly silenced tumor suppressor genes whose DNA is hypermethylated. SIRT1 has a role associated with the epigenetic hallmarks of cancer. Conclusion: The link between SIRT6 and cancer provide new insight into the therapeutic potential of small molecule activators or specific targets of SIRT6 for the prevention and treatment of cancer. Further investigation into the specific mechanism of SIRT6 is required to realize this potential.
机译：简介：癌症是一组以异常细胞的失控生长和扩散为特征的疾病。如果传播不受控制，可能会导致死亡。 Sirtunins属于蛋白质家族，它存在于所有生物中。 SIRT6在肿瘤中下调，并起抑癌作用。这些Sirtunin蛋白与修复DNA和代谢有关。材料和方法：为了测量SIRT6在肿瘤细胞中的作用，使用了20只小鼠，并使用欧洲细胞培养物保藏中心（ECACC）细胞系进行了分析。组织病理学技术显示了肿瘤细胞的水平。结果：最近的一项研究提供了对SIRT6相关染色质调节机制的独特见解。根据癌症的组织病理学，SIRT1定位于DNA高度甲基化的几个异常沉默的抑癌基因的启动子。 SIRT1具有与癌症的表观遗传学特征相关的作用。结论：SIRT6与癌症之间的联系为小分子激活剂或SIRT6的特定靶标在预防和治疗癌症方面的治疗潜力提供了新的见识。为了实现这一潜力，需要对SIRT6的特定机制进行进一步研究。

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