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首页> 外文期刊>European Journal of Histochemistry >Distribution of NADPH-diaphorase and AChE activity in the anterior leaflet of rat mitral valve
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Distribution of NADPH-diaphorase and AChE activity in the anterior leaflet of rat mitral valve

机译：大鼠二尖瓣前叶中NADPH心肌黄递酶和AChE活性的分布

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摘要

The mraitcratl valve, as an active flap, forms the major part of the left ventricular inflow tract and therefore plays an important function in many aspects of left ventricular performance. The anterior leaflet of this valve is the largest and most ventrally placed of two leaflets that come together during ventricular systole to close the left atrioventricular orifice. Various neurotransmitters are responsible for different functions including controlling valve movement, inhibiting or causing the failure of impulse conduction in the valve and the sensation of pain. Nitric oxide acts as a gaseous free radical neurotransmitter, neuromediator and effective cardiovascular modulator. Acetyl-choline is known to function as a typical neurotransmitter. Histochemical methods for detection of nicotinamide adenine dinucleotide phosphate diaphorase (NADPH-d), as an indirect nitric oxide-synthase marker, and method for detection of acetylcholinesterase (AChE) were used. Both methods were performed on the same valve sampl. A widespread distribution of nerve fibres was observed in the anterior leaflet of the mitral valve. The fine NADPH-d positive (nitrergic) nerve fibres were identified in all zones of valve leaflet. AChE positive (cholinergic) nerve fibres were identified forming dense network and fibres organized in stripes. Endocardial cells and vessels manifested heavy NADPH-d activity. Our observations suggest a different arrangement of nitrergic and cholinergic nerve fibres in the anterior leaflet of the mitral valve. The presence of nitrergic and cholinergic activity confirms the involvement of both neurotransmitters in nerve plexuses and other structures of mitral valve.
机译：crat瓣作为活动瓣，形成左心室流入道的主要部分，因此在左心室表现的许多方面起着重要的作用。该瓣膜的前小叶是两个小叶中最大，最靠腹的位置，在心室收缩期间两个小叶汇聚在一起以关闭左房室孔。各种神经递质负责不同的功能，包括控制瓣膜运动，抑制或导致瓣膜冲动传导失败和疼痛感。一氧化氮可作为气态自由基神经递质，神经介质和有效的心血管调节剂。已知乙酰胆碱起典型的神经递质的作用。作为间接一氧化氮合酶标记，使用了组织化学方法检测烟酰胺腺嘌呤二核苷酸磷酸黄递酶（NADPH-d）和乙酰胆碱酯酶（AChE）。两种方法均在相同的阀门样品上进行。在二尖瓣的前瓣中观察到神经纤维的广泛分布。在瓣膜小叶的所有区域均鉴定出了细的NADPH-d阳性（神经营养）神经纤维。鉴定出AChE阳性（胆碱能）神经纤维形成密集的网络，纤维组织成条纹。心内膜细胞和血管表现出重的NADPH-d活性。我们的观察结果提示二尖瓣前小叶中硝化和胆碱能神经纤维的排列不同。硝酸和胆碱能活性的存在证实了神经递质参与了神经丛和二尖瓣其他结构。

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