Failure to detect DUP25 in lymphoblastoid cells derived from patients with panic disorder and control individuals representing European and American populations.

Zhu G; Bartsch O; Skrypnyk C; Rotondo A; Akhtar LA; Harris C; Virkkunen M; Cassano G; Goldman D

首页> 外文期刊>European journal of human genetics: EJHG >Failure to detect DUP25 in lymphoblastoid cells derived from patients with panic disorder and control individuals representing European and American populations.

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Failure to detect DUP25 in lymphoblastoid cells derived from patients with panic disorder and control individuals representing European and American populations.

机译：无法在恐慌症患者和代表欧美人群的对照个体的淋巴母细胞中检测DUP25。

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Investigation of the co-occurrence of panic and phobic disorders with joint laxity led to the identification of interstitial duplications involving human chromosome 15q24-26 (named 'DUP25') in a Spanish population. DUP25 was observed in 97% of patients and in 7% of control individuals. In the present study, we used two different methods to detect DUP25: high-throughput molecular gene dosage analysis and fluorescence in situ hybridization (FISH). We evaluated 56 lymphoblastoid cell lines derived from 26 unrelated patients with panic disorder obtained from several European and American populations and 30 normal controls. We could not find any cell line showing a result consistent with DUP25. These data do not support any association of DUP25 with panic disorder.

机译：对恐慌症和恐怖症与关节松弛共同发生的调查，导致在西班牙人群中鉴定出涉及人染色体15q24-26（称为“ DUP25”）的间质重复。在97％的患者和7％的对照个体中观察到DUP25。在本研究中，我们使用了两种不同的方法来检测DUP25：高通量分子基因剂量分析和荧光原位杂交（FISH）。我们评估了56个淋巴母细胞细胞系，这些细胞系来自26个无关的恐慌症患者，这些患者来自几个欧美人群和30个正常对照。我们找不到任何显示与DUP25一致的结果的细胞系。这些数据不支持DUP25与恐慌症的任何关联。

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来源
《European journal of human genetics: EJHG》 |2004年第6期|共4页
作者
Zhu G; Bartsch O; Skrypnyk C; Rotondo A; Akhtar LA; Harris C; Virkkunen M; Cassano G; Goldman D;
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正文语种 eng
中图分类基础医学;
关键词
Panic Disorder; American; control; EUROPEAN; Personal failure; 惊恐病;

机译：Panic Disorder;American;control;EUROPEAN;Personal failure;惊恐病;

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1. Failure to detect DUP25 in lymphoblastoid cells derived from patients with panic disorder and control individuals representing European and American populations. [J] . Zhu G, Bartsch O, Skrypnyk C, European journal of human genetics: EJHG . 2004,第6期

机译：无法在恐慌症患者和代表欧美人群的对照个体的淋巴母细胞中检测DUP25。
2. Generation and characterization of individual-specific induced pluripotent cells from patient-derived lymphoblastoid cell lines [J] . Shadaan Zulfiqar, Radhika Menon, Tara Atmaram, Molecular neurodegeneration . 2013,第S1期

机译：源自患者的淋巴母细胞样细胞系的个体特异性诱导多能细胞的生成和表征
3. Clinical and sociocultural differences in African American and European American patients with panic disorder and agoraphobia. [J] . Smith LC, Friedman S, Nevid J The Journal of Nervous and Mental Disease . 1999,第9期

机译：非洲裔美国人和欧洲裔恐慌症和广场恐惧症患者的临床和社会文化差异。
4. The effectiveness of existential art therapy on locus of control, self-efficacy, and self-esteem on the mobility and cognitions of individuals diagnosed with panic disorder. [D] . Crystal, Jennifer Page. 2001

机译：存在的艺术疗法对被诊断为恐慌症的个体的控制源，自我效能感和自尊心的有效性。
5. Failure to Find DUP25 in Patients with Anxiety Disorders in Control Individuals or in Previously Reported Positive Control Cell Lines [O] . Melody Tabiner, Sheila Youings, Nicholas Dennis, 2003

机译：在焦虑症患者对照个体或先前报道的阳性对照细胞系中未找到DUP25
6. Failure to Find DUP25 in Patients with Anxiety Disorders, in Control Individuals, or in Previously Reported Positive Control Cell Lines [O] . Tabiner, Melody, Youings, Sheila, Dennis, Nicholas, 2003

机译：在焦虑症患者，对照个体或先前报道的阳性对照细胞系中未找到DUP25

Failure to detect DUP25 in lymphoblastoid cells derived from patients with panic disorder and control individuals representing European and American populations.

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