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首页> 外文期刊>European Journal of Histochemistry >An immunohistochemical study of matrix proteins in the craniofacial cartilage in midterm human fetuses
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An immunohistochemical study of matrix proteins in the craniofacial cartilage in midterm human fetuses

机译：中期胎儿胎儿颅面软骨中基质蛋白的免疫组织化学研究

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Immunohistochemical localization of collagen types I, II, and X, aggrecan, versican, dentin matrix protein (DMP)-1, martix extracellular phosphoprotein (MEPE) were performed for Meckel's cartilage, cranial base cartilage, and mandibular condylar cartilage in human midterm fetuses; staining patterns within the condylar cartilage were compared to those within other cartilaginous structures. Mandibular condylar cartilage contained aggrecan; it also had more type I collagen and a thicker hypertrophic cell layer than the other two types of cartilage; these three characteristics are similar to those of the secondary cartilage of rodents. MEPE immunoreactivity was first evident in the cartilage matrix of all types of cartilage in the human fetuses and in Meckel's cartilage of mice and rats. MEPE immunoreactivity was enhanced in the deep layer of the hypertrophic cell layer and in the cartilaginous core of the bone trabeculae in the primary spongiosa. These results indicated that MEPE is a component of cartilage matrix and may be involved in cartilage mineralization. DMP-1 immunoreactivity first became evident in human bone lacunae walls and canaliculi; this pattern of expression was comparable to the pattern seen in rodents. In addition, chondroid bone was evident in the mandibular (glenoid) fossa of the temporal bone, and it had aggrecan, collagen types I and X, MEPE, and DMP-1 immunoreactivity; these findings indicated that chondroid bone in this region has phenotypic expression indicative of both hypertrophic chondrocytes and osteocytes.
机译：对人中期胎儿的Meckel软骨，颅底软骨和下颌con突软骨进行了I，II和X型胶原，聚集蛋白聚糖，versican，牙本质基质蛋白（DMP）-1，martix细胞外磷蛋白（MEPE）的免疫组织化学定位;将con突软骨内的染色模式与其他软骨结构内的染色模式进行了比较。下颌con突软骨中含有蛋白聚糖。与其他两种类型的软骨相比，它还具有更多的I型胶原和较厚的肥大细胞层。这三个特征与啮齿动物的继发软骨相似。 MEPE免疫反应性首先出现在人类胎儿所有类型的软骨以及小鼠和大鼠的Meckel软骨中。 MEPE免疫反应性在原发性海绵宝宝的肥大细胞层的深层和骨小梁的软骨核心中增强。这些结果表明，MEPE是软骨基质的成分，可能与软骨矿化有关。 DMP-1免疫反应性首先在人的骨腔壁和小管中变得明显。这种表达方式可与啮齿动物看到的方式媲美。此外，软骨样骨在颞骨的下颌（盂）窝中很明显，并且具有聚集蛋白聚糖，I型和X型胶原，MEPE和DMP-1免疫反应性。这些发现表明，该区域的软骨样骨具有表型表达，指示肥大的软骨细胞和骨细胞。

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