...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>European journal of human genetics: EJHG >The role of GHR and IGF1 genes in the genetic determination of African pygmies' short stature.
【24h】

The role of GHR and IGF1 genes in the genetic determination of African pygmies' short stature.

机译：GHR和IGF1基因在非洲矮小矮个子的遗传测定中的作用。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

African pygmies are at the lower extreme of human variation in adult stature and many evolutionary hypotheses have been proposed to explain this phenotype. We showed in a recent study that the difference in average stature of about 10 cm observed between contemporary pygmies and neighboring non-pygmies has a genetic component. Nevertheless, the genetic basis of African pygmies' short stature remains unknown. Using a candidate-gene approach, we show that intronic polymorphisms in GH receptor (GHR) and insulin-like growth factor 1 (IGF1) genes present outlying values of the genetic distance between Baka pygmies and their non-pygmy Nzimé neighbors. We further show that GHR and IGF1 genes have experienced divergent natural selection pressures between pygmies and non-pygmies throughout evolution. In addition, these SNPs are associated with stature in a sample composed of 60 pygmies and 30 non-pygmies and this association remains significant when correcting for population structure for the GHR locus. We conclude that the GHR and IGF1 genes may have a role in African pygmies' short stature. The use of phenotypically contrasted populations is a promising strategy to identify new variants associated with complex traits in humans.
机译：非洲侏儒处于人类成年身材变异的最低端，并且提出了许多进化假设来解释这种表型。我们在最近的一项研究中表明，当代侏儒和邻近的非侏儒之间的平均身高差异约为10厘米，这是遗传因素造成的。然而，非洲侏儒矮小的遗传基础仍然未知。使用候选基因方法，我们显示GH受体（GHR）和胰岛素样生长因子1（IGF1）基因的内含子多态性显示了巴卡格米人与非py格米人Nzimé邻居之间遗传距离的外在值。我们进一步表明，在整个进化过程中，GHR和IGF1基因在侏儒和非侏儒之间经历了不同的自然选择压力。此外，在由60个with格小人和30个非-格小人组成的样本中，这些SNP与身材相关，在校正GHR位点的种群结构时，这种关联仍然很重要。我们得出的结论是，GHR和IGF1基因可能在非洲侏儒矮个子中起作用。表型上有差异的人群的使用是一种有前途的策略，可用于识别与人类复杂性状相关的新变异。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号