Synthesis and antiinflammatory activity of heterocyclic indole derivatives.

Rani P; Srivastava VK; Kumar A

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Synthesis and antiinflammatory activity of heterocyclic indole derivatives.

机译：杂环吲哚衍生物的合成及其抗炎活性。

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Chalcones of indole 1-5 and their corresponding products; pyrazolines 6-10 and azo compounds 11-15 were synthesised and evaluated for their antiinflammatory activity against carrageenan induced oedema in albino rats at a dose of 50 mg kg(-1) oral. The structure of compounds was confirmed by IR, (1)H-NMR and mass spectral data. All the compounds of this series showed promising antiinflammatory activity. The most active compound of this series is 3-[1-acetyl-5-(p-hydroxyphenyl)-2-pyrazolin-3-yl]indole (7) was found to be most potent, which has shown higher percent of inhibition of oedema, lower ulcerogenic liability and acute toxicity than the standard drug phenylbutazone.

机译：吲哚1-5的查尔酮及其相应产品;合成吡唑啉6-10和偶氮化合物11-15，并以50 mg kg（-1）口服剂量评估其对角叉菜胶诱发的水肿的抗炎活性。化合物的结构通过IR，（1）H-NMR和质谱数据确认。该系列的所有化合物均显示出有希望的抗炎活性。该系列中活性最高的化合物是3- [1-乙酰基-5-（对羟基苯基）-2-吡唑啉-3-基]吲哚（7）最有效，已显示出较高的抑制率。与标准药物苯基丁a相比，水肿，致溃疡作用和急性毒性较低。

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《European Journal of Medicinal Chemistry: Chimie Therapeutique》 |2004年第5期|共4页
作者
Rani P; Srivastava VK; Kumar A;
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正文语种 eng
中图分类基础医学;
关键词
indole; Synthesis; derivatives; albino rat;

机译：吲哚;合成;衍生物;白化大鼠;

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1. Synthesis and antiinflammatory activity of heterocyclic indole derivatives. [J] . Rani P, Srivastava VK, Kumar A European Journal of Medicinal Chemistry: Chimie Therapeutique . 2004,第5期

机译：杂环吲哚衍生物的合成及其抗炎活性。
2. Condensed bridgehead nitrogen heterocyclic systems:Synthesis and antimicrobial activity of thiazolo[3', 2': 2, 3]-as-triazino[5, 6-b]indoles and isomeric thiazolo[2', 3': 3, 4]-as-triazino[5, 6-b]indoles 8. The unequivocal synthesis of 8 has also bee [J] . Jag Mohan, nupama Indian Journal of Chemistry, Section B. Organic Including Medicinal . 2002,第3期

机译：缩合桥头氮杂环系统：噻唑[3'，2'：2，3]-三嗪[5，6-b]吲哚和异构体噻唑[2'，3'：3，4]-的合成及抑菌活性as-triazino [5，6-b]吲哚8。8的明确合成也有蜜蜂
3. Synthesis and biological activity of 8beta-substituted hydrocodone indole and hydromorphone indole derivatives. [J] . Yu Han, Prisinzano Thomas, Dersch ChristinaM, Bioorganic and Medicinal Chemistry Letters . 2002,第2期

机译：8β-取代的氢可酮吲哚和氢吗啡酮吲哚衍生物的合成及生物活性。
4. Synthesis and in vivo antiinflammatory activity of long chain 2-amino-alcohols [C] . Violetta Constantinou-Kokotou, Victoria Magrioti, Dinitra Hadjipavlou-Litina European Peptide Symposium . 2002

机译：长链2-氨基醇的合成和体内抗炎活性
5. Studies into the Biosynthesis and Chemical Synthesis of Indolocarbazoles and Related Heterocyclic Compounds. Metalation of Indole-6-Carboxamide. [D] . Groom, Katherine A. 2013

机译：吲哚并咔唑及其相关杂环化合物的生物合成和化学合成研究。吲哚6-羧酰胺的金属化。
6. Synthesis and Antiproliferative Activity of Novel Heterocyclic Indole-Trimethoxyphenyl Conjugates [O] . Michael M. Cahill, Kevin D. O’Shea, Larry T. Pierce, 2017

机译：新型杂环吲哚-三甲氧基苯基缀合物的合成及抗增殖活性
7. Furo(3,2-b)indole derivatives. I. Synthesis and analgesic and anti-inflammatory activities of 4,6-disubstituted-furo(3,2-b)indole-2-carboxamide derivatives. [O] . YOSHIMOTO NAKASHIMA, YUTAKA KAWASHIMA, FUSAO AMANUMA, 1984

机译：呋喃（3,2-B）吲哚衍生物。 I. 4,6-二取代 - 呋喃（3,2-B）吲哚-2-甲酰胺衍生物的合成和镇痛和抗炎活性。

Synthesis and antiinflammatory activity of heterocyclic indole derivatives.

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