Synthesis and anti-bacterial activity of some novel 2-(6-fluorochroman-2-yl)-1-alkyl/acyl/aroyl-1H-benzimidazoles.

Kumar BV; Vaidya SD; Kumar RV; Bhirud SB; Mane RB

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Synthesis and anti-bacterial activity of some novel 2-(6-fluorochroman-2-yl)-1-alkyl/acyl/aroyl-1H-benzimidazoles.

机译：一些新型的2-（6-氟代苯并-2-基）-1-烷基/酰基/芳酰基-1H-苯并咪唑类化合物的合成和抗菌活性。

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Synthesis of some novel 2-(6-fluorochroman-2-yl)-1-alkyl/acyl/aroyl-1H-benzimidazoles by the condensation of o-phenylenediamine with 6-fluoro-3,4-dihydro-2H-chroman-2-carboxylic acid, and subsequent reactions with different types of electrophiles, have been reported. Some compounds exhibited promising anti-bacterial activity against Salmonella typhimurium; however, they showed poor activity against S. aureus. The biological activity against PDE IV for potential anti-asthamatic effect, and against DP-IV and PTP 1B for potential anti-diabetic effects was disappointing.

机译：通过邻苯二胺与6-氟-3,4-二氢-2H-chroman-2的缩合反应合成一些新颖的2-（6-氟代铬-2-基）-1-烷基/酰基/芳酰基-1H-苯并咪唑-羧酸，以及随后与不同类型的亲电试剂的反应，已有报道。一些化合物显示出对鼠伤寒沙门氏菌的有希望的抗菌活性。但是，它们对金黄色葡萄球菌的活性较弱。令人失望的是针对PDE IV的潜在抗流失作用以及针对DP-IV和PTP 1B的生物活性令人失望。

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来源
《European Journal of Medicinal Chemistry: Chimie Therapeutique》 |2006年第5期|共6页
作者
Kumar BV; Vaidya SD; Kumar RV; Bhirud SB; Mane RB;
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正文语种 eng
中图分类基础医学;
关键词
Synthesis; novel; Benzimidazoles; Roman Numeral IV; Financially poor; 苯咪唑类;

机译：Synthesis;novel;Benzimidazoles;Roman Numeral IV;Financially poor;苯咪唑类;

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1. Synthesis and anti-bacterial activity of some novel 2-(6-fluorochroman-2-yl)-1-alkyl/acyl/aroyl-1H-benzimidazoles. [J] . Kumar BV, Vaidya SD, Kumar RV, European Journal of Medicinal Chemistry: Chimie Therapeutique . 2006,第5期

机译：一些新型的2-（6-氟代苯并-2-基）-1-烷基/酰基/芳酰基-1H-苯并咪唑类化合物的合成和抗菌活性。
2. Synthesis and antibacterial activity of somenovel N-substituted 3-[4-(1-alkyl/acyl/aroyl-1H-benzimidazol-2-yl)phenyl]acrylatederivatives [J] . Raju B Chaudhari, Sanjay D Vaidya, B K Karale Indian Journal of Chemistry, Section B. Organic Including Medicinal . 2011,第9期

机译：某些新颖的N-取代的3- [4-（1-烷基/酰基/芳酰基-1H-苯并咪唑-2-基）苯基]丙烯酸酯衍生物的合成和抗菌活性
3. Synthesis, characterization and anti-bacterial activity of 5-(alkenyl)-2- amino- and 2-(alkenyl)-5-phenyl-1,3,4-oxadiazoles [J] . Abdul Rauf1, Mudasir R Banday, Rayees H Mattoo Journal of Chemical Sciences . 2010,第2期

机译：5-（烯基）-2-氨基-和2-（烯基）-5-苯基-1,3,4-恶二唑的合成，表征和抗菌活性
4. O-Acyl isopeptide method for peptide synthesis: Application of O-acyl isodipeptide units to the synthesis of bioactive peptides [C] . Naoko Abe, Atsuhiko Taniguchi, Taku Yoshiya International Peptide Symposium . 2009

机译：肽合成的O-酰基异肽方法：将O-酰基异肽单元施用于生物活性肽的合成
5. Design and synthesis of a library of novel aminosugars and the anti-bacterial activity of a new class of aminoglycoside antibiotics. [D] . Elchert, Bryan. 2004

机译：设计和合成新型氨基糖文库和新型氨基糖苷类抗生素的抗菌活性。
6. Synthesis of novel 5-alkyl/aryl/heteroaryl substituted diethyl 34-dihydro-2H-pyrrole-44-dicarboxylates by aziridine ring expansion of 2-(aziridin-1-yl)-1-alkyl/aryl/heteroaryl-methylenemalonic acid diethyl esters [O] . Satish S More, T Krishna Mohan, Y Sateesh Kumar, 2011

机译：通过2-（（叠氮基-1-基）-1-烷基 -1-烷基/芳基/杂芳基的氮丙啶扩环合成新颖的5-烷基/芳基/杂芳基取代的34-二氢-2H-吡咯-44-二羧酸二乙酯-亚甲基丙二酸二乙酯
7. Synthesis, anti-bacterial, anti-asthmatic and anti-diabetic activities of novel N-substituted 2-(4-styrylphenyl)-1H-benzimidazole and N- substituted-3[4-(1H-benzimidazole-2-yl)-phenyl]-acrylic acid tert-butyl ester [O] . Ramanatham Vinodkumar, Sanjay Dashrath Vaidya, Bobba Venkata Siva Kumar, 2008

机译：新型N-取代2-（4-苯乙烯基苯基）-1H-苯并咪唑和N-取代-3 [4-（1H-苯并咪唑-2-基） - 苯基的合成，抗菌，抗哮喘和抗糖尿病活性] - 丙烯酸叔丁酯

Synthesis and anti-bacterial activity of some novel 2-(6-fluorochroman-2-yl)-1-alkyl/acyl/aroyl-1H-benzimidazoles.

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