Synthesis, characterization and cytotoxicity of mixed-ligand complexes of palladium(II) with aromatic diimine and 4-toluenesulfonyl-L-amino acid dianion.

Zhang J; Li L; Wang L; Zhang F; Li X

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Synthesis, characterization and cytotoxicity of mixed-ligand complexes of palladium(II) with aromatic diimine and 4-toluenesulfonyl-L-amino acid dianion.

机译：钯（II）与芳族二亚胺和4-甲苯磺酰基-L-氨基酸二阴离子的混合配体配合物的合成，表征和细胞毒性。

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Eight new palladium(II) complexes (1a-2d) with 4-toluenesulfonyl-l-amino acid dianion and diimine (bipy and phen) have been synthesized and characterized by elemental analysis, IR, UV, (1)H NMR, (13)C NMR and mass spectra techniques. Crystal structure of the complex (2d) has been determined by X-ray diffraction analysis. The cytotoxicity was tested by MTT and SRB assays. The results indicate that the complexes (1a-2d) have selectivity against tested carcinoma cell lines. The complex (2c) has the best cytotoxicity among the eight complexes, moreover its cytotoxicity is better than that of cisplatin against BGC-823, Bel-7402 and KB cell lines. It suggests that both aromatic diimine and 4-toluenesulfonyl-L-amino acid have important effect on cytotoxicity.

机译：合成了八种新的钯（II）配合物（1a-2d），其中有4-甲苯磺酰基-1-氨基酸的二价阴离子和二亚胺（联吡啶和苯酚），并通过元素分析，红外，紫外，（1）H NMR进行了表征，（13 C NMR和质谱技术。配合物（2d）的晶体结构已经通过X射线衍射分析确定。细胞毒性通过MTT和SRB测定法测试。结果表明，复合物（1a-2d）对测试的癌细胞系具有选择性。该复合物（2c）在八种复合物中具有最佳的细胞毒性，而且其对BGC-823，Bel-7402和KB细胞系的细胞毒性优于顺铂。这表明芳族二亚胺和4-甲苯磺酰基-L-氨基酸均对细胞毒性具有重要作用。

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《European Journal of Medicinal Chemistry: Chimie Therapeutique》 |2010年第11期|共8页
作者
Zhang J; Li L; Wang L; Zhang F; Li X;
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1. Synthesis, characterization and cytotoxicity of mixed-ligand complexes of palladium(II) with aromatic diimine and 4-toluenesulfonyl-L-amino acid dianion. [J] . Zhang J, Li L, Wang L, European Journal of Medicinal Chemistry: Chimie Therapeutique . 2010,第11期

机译：钯（II）与芳族二亚胺和4-甲苯磺酰基-L-氨基酸二阴离子的混合配体配合物的合成，表征和细胞毒性。
2. Synthesis, characterization and cytotoxicity of mixed-ligand complexes of palladium(II) with aromatic diimine and 4-toluenesulfonyl-L-amino acid dianion. [J] . Zhang J, Li L, Wang L, European Journal of Medicinal Chemistry: Chimie Therapeutique . 2010,第11期

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3. Synthesis, characterization and cytotoxicity of mixed-ligand complexes of palladium(II) with 2, 2'-biquinoline/1, 4-diaminobutane and 4-toluenesulfonyl-L-amino acid dianion. [J] . Zhang J, Li L, Ma L, European Journal of Medicinal Chemistry: Chimie Therapeutique . 2011,第11期

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4. Synthesis, Characterization and Third Order Nonlinear Optical Studies of Diimine Based Zn(II), Cd(II) and Hg(II) Complexes [C] . B. J. Rudresha, B. Ramachandra Bhat, K. B. Manjunatha, International Conference on Light . 2011

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Synthesis, characterization and cytotoxicity of mixed-ligand complexes of palladium(II) with aromatic diimine and 4-toluenesulfonyl-L-amino acid dianion.

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