Synthesis and potent antibacterial activity against MRSA of some novel 1,2-disubstituted-1H-benzimidazole-N-alkylated-5-carboxamidines.

Goker H; Ozden S; Yildiz S; Boykin DW

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Synthesis and potent antibacterial activity against MRSA of some novel 1,2-disubstituted-1H-benzimidazole-N-alkylated-5-carboxamidines.

机译：一些新型的1,2-二取代-1H-苯并咪唑-N-烷基化-5-甲am的合成及对MRSA的强效抗菌活性。

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摘要

A series of 28 novel 1,2-disubstituted-1H-benzimidazole-N-alkylated-5-carboxamidine derivatives were synthesized and evaluated for in vitro antibacterial activities against Staphylococcus aureus and methicillin resistant S. aureus (MRSA) by the tube dilution method. The results showed that compounds 45-46 and 55-57, having 3,4-dichloro substituted phenyl at the position C-2, of N-bulky alkyl substituted benzimidazolecarboxamidines exhibited the greatest activity with MIC values of 1.56-0.39 microg/ml.

机译：合成了28种新颖的1,2-二取代-1H-苯并咪唑-N-烷基化-5-甲car衍生物，并通过试管稀释法评估了其对金黄色葡萄球菌和耐甲氧西林金黄色葡萄球菌（MRSA）的体外抗菌活性。结果表明，N-稠烷基取代的苯并咪唑甲酰胺的C-2位具有3，4-二氯取代的苯基的化合物45-46和55-57表现出最大的活性，MIC值为1.56-0.39μg/ ml。

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《European Journal of Medicinal Chemistry: Chimie Therapeutique》 |2005年第10期|共8页
作者
Goker H; Ozden S; Yildiz S; Boykin DW;
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原文格式 PDF
正文语种 eng
中图分类基础医学;
关键词
novel; Methicillin-resistant staphylococcus aureus infection; benzimidazole;

机译：新型;耐甲氧西林金黄色葡萄球菌感染;苯并咪唑;

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1. Synthesis and potent antibacterial activity against MRSA of some novel 1,2-disubstituted-1H-benzimidazole-N-alkylated-5-carboxamidines. [J] . Goker H, Ozden S, Yildiz S, European Journal of Medicinal Chemistry: Chimie Therapeutique . 2005,第10期

机译：一些新型的1,2-二取代-1H-苯并咪唑-N-烷基化-5-甲am的合成及对MRSA的强效抗菌活性。
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Synthesis and potent antibacterial activity against MRSA of some novel 1,2-disubstituted-1H-benzimidazole-N-alkylated-5-carboxamidines.

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