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首页> 外文期刊>European Journal of Medicinal Chemistry: Chimie Therapeutique >Syntheses and odor of 'bulky group'-modified sandalwood odorants: isophorono-beta-santalol analogues.
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Syntheses and odor of 'bulky group'-modified sandalwood odorants: isophorono-beta-santalol analogues.

机译：“大块”修饰的檀香加香剂的合成和气味：异佛尔酮-β-檀香醇类似物。

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Three osmophoric points have been found to be necessary for the scent of sandalwood odorants. One of these points is the bulky group in a certain distance from the osmophoric hydroxyl group. Such a hydrophobic moiety is part of the trimethylcyclopentenyl derivatives, the so called campholenals, among them many are known to exert a strong and long lasting sandalwood odor. In continuation of our SAR-studies of sandalwood odorants four isophorone analogues of beta-santalol have been synthesized. The hydrophobic region of these new isophorone derivatives is now a trimethylcyclohexene nucleus, so to speak an extension of the cyclopentene part of the campholenals by one methylene group. This modification changes the sandalwood odor drastically to woody odor notes, reminiscent only to sandalwood odor. The environs of the crowded trimethylcyclohexene nucleus demonstrate the sensitivity of sandalwood odor on the shape of the hydrophobic, bulky part of beta-santalol analogues.
机译：已经发现三个渗透点对于檀香加味剂的气味是必要的。这些要点之一是离渗透性羟基一定距离的庞大基团。这样的疏水部分是三甲基环戊烯基衍生物的一部分，所谓的樟脑醛，其中许多已知的会散发出强烈而持久的檀香气味。在我们对檀香加味剂的SAR研究中，已合成了β-檀香醇的四种异佛尔酮类似物。这些新的异佛尔酮衍生物的疏水区现在是三甲基环己烯核，可以说是樟脑环的环戊烯部分被一个亚甲基延伸。此修改将檀香的气味彻底变为木质的气味，仅使人联想到檀香的气味。拥挤的三甲基环己烯核的周围环境显示出檀香气味对β-檀香醇类似物的疏水大体积部分的形状敏感。

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