Synthesis and cytotoxicity evaluation of some benzimidazole-4,7-diones as bioreductive anticancer agents.

Gellis A; Kovacic H; Boufatah N; Vanelle P

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Synthesis and cytotoxicity evaluation of some benzimidazole-4,7-diones as bioreductive anticancer agents.

机译：某些苯并咪唑-4,7-二酮类化合物作为生物还原抗癌剂的合成及细胞毒性评估。

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New benzimidazole-4,7-diones substituted at 2-position were synthesized via a microwave-assisted reaction using 2-chloromethyl-1,5,6-trimethyl-1H-benzimidazole-4,7-dione 5b as a key intermediate compound. Their cytotoxicity has been evaluated on colon, breast and lung cancer cell lines. The dimer 17 was shown to possess excellent cytotoxicity comparable to that of mitomycin C.

机译：通过微波辅助反应，以2-氯甲基-1,5,6-三甲基-1H-苯并咪唑-4,7-二酮5b为关键中间体化合物，通过微波辅助反应合成了在2-位取代的新苯并咪唑-4,7-二酮。已经对结肠，乳腺癌和肺癌细胞系评估了它们的细胞毒性。显示二聚体17具有与丝裂霉素C相当的优异的细胞毒性。

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来源
《European Journal of Medicinal Chemistry: Chimie Therapeutique》 |2008年第9期|共7页
作者
Gellis A; Kovacic H; Boufatah N; Vanelle P;
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原文格式 PDF
正文语种 eng
中图分类医药、卫生;劳动卫生;
关键词
Cytotoxicity; benzimidazole; Synthesis; Evaluation; dimer;

机译：细胞毒性苯并咪唑合成评价二聚体;

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1. Synthesis and cytotoxicity evaluation of some benzimidazole-4,7-diones as bioreductive anticancer agents. [J] . Gellis A, Kovacic H, Boufatah N, European Journal of Medicinal Chemistry: Chimie Therapeutique . 2008,第9期

机译：某些苯并咪唑-4,7-二酮类化合物作为生物还原抗癌剂的合成及细胞毒性评估。
2. Synthesis, Anticancer Activity and UPLC Analysis of the Stability of Some New Benzimidazole-4,7-dione Derivatives [J] . Katarzyna B?aszczak-?wi?tkiewicz, Diogo Almeida, Maria Perry, Molecules . 2014,第1期

机译：一些新型苯并咪唑-4,7-二酮衍生物的合成，抗癌活性和UPLC分析
3. Synthesis and biological evaluation of benzimidazole-4,7-diones that inhibit vascular smooth muscle cell proliferation. [J] . Hong SY, Chung KH, You HJ, Bioorganic and Medicinal Chemistry Letters . 2004,第13期

机译：抑制血管平滑肌细胞增殖的苯并咪唑-4,7-二酮的合成和生物学评估。
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机译：第二代和第三代紫杉类抗癌药的合成及生物学评价。
6. Antitumor Agents. 271. Total Synthesis and Evaluation of Brazilein and Analogs as Anti-inflammatory and Cytotoxic Agents [O] . Chiao-Ting Yen, Kyoko Nakagawa-Goto, Tsong-Long Hwang, -1

机译：抗肿瘤剂。 271.含有抗炎和细胞毒性剂的碱性合成和评价和评价
7. Synthesis, Anticancer Activity and UPLC Analysis of the Stability of Some New Benzimidazole-4,7-dione Derivatives [O] . Katarzyna Błaszczak-Świątkiewicz, Diogo Correia Almeida, Maria De Jesus Perry, 2013

机译：新型苯并咪唑-4,7-二酮衍生物稳定性的合成，抗癌活性和UpLC分析

Synthesis and cytotoxicity evaluation of some benzimidazole-4,7-diones as bioreductive anticancer agents.

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