Synthesis and alpha(1)-antagonist activity of derivatives of 4-chloro-5-(4-(2-(2-methoxyphenoxy)-ethyl)-1-piperazinyl)-3(2H)-pyrid azinone.

Strappaghetti G; Barbaro R; Marucci G

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Synthesis and alpha(1)-antagonist activity of derivatives of 4-chloro-5-(4-(2-(2-methoxyphenoxy)-ethyl)-1-piperazinyl)-3(2H)-pyrid azinone.

机译：4-氯-5-（4-（2-（2-（2-甲氧基苯氧基）-乙基）-1-哌嗪基）-3（2H）-吡啶氮嗪酮衍生物的合成及α（1）-拮抗剂活性。

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摘要

The synthesis and evaluation of the biological activity of new 4-chloro-5-{4-[2-(2-methoxyphenoxy)-ethyl]-1-piperazinyl}-3(2H)-pyrid azinone derivatives are reported. The blocking activity of these compounds was determined on the pre- and postsynaptic alpha-adrenoceptors of isolated rat vas deferens.

机译：报道了新的4-氯-5- {4- [2- [2-（2-甲氧基苯氧基）-乙基] -1-哌嗪基} -3（2H）-吡啶氮嗪酮衍生物的合成和生物活性。在分离的大鼠输精管的突触前和突触后α-肾上腺素受体上测定了这些化合物的阻断活性。

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《European Journal of Medicinal Chemistry: Chimie Therapeutique》 |2000年第8期|共7页
作者
Strappaghetti G; Barbaro R; Marucci G;
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正文语种 eng
中图分类医药、卫生;
关键词
Adrenergic alpha-Agonists; Piperazines; Pyridazines; Receptors; Adrenergic; alpha-1; 肾上腺素能α激动剂; 哌嗪类; 哒嗪类;

机译：Adrenergic alpha-Agonists;Piperazines;Pyridazines;Receptors;Adrenergic;alpha-1;肾上腺素能α激动剂;哌嗪类;哒嗪类;

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1. Synthesis and alpha(1)-antagonist activity of derivatives of 4-chloro-5-(4-(2-(2-methoxyphenoxy)-ethyl)-1-piperazinyl)-3(2H)-pyrid azinone. [J] . Strappaghetti G, Barbaro R, Marucci G European Journal of Medicinal Chemistry: Chimie Therapeutique . 2000,第7a8期

机译：4-氯-5-（4-（2-（2-（2-甲氧基苯氧基）-乙基）-1-哌嗪基）-3（2H）-吡啶氮嗪酮衍生物的合成及α（1）-拮抗剂活性。
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Synthesis and alpha(1)-antagonist activity of derivatives of 4-chloro-5-(4-(2-(2-methoxyphenoxy)-ethyl)-1-piperazinyl)-3(2H)-pyrid azinone.

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