Aqua mediated synthesis of 2-amino-6-benzothiazol-2-ylsulfanyl-chromenes and its in vitro study, explanation of the structure-activity relationships (SARs) as antibacterial agent.

Kidwai M; Poddar R; Bhardwaj S; Singh S; Luthra PM

首页> 外文期刊>European Journal of Medicinal Chemistry: Chimie Therapeutique >Aqua mediated synthesis of 2-amino-6-benzothiazol-2-ylsulfanyl-chromenes and its in vitro study, explanation of the structure-activity relationships (SARs) as antibacterial agent.

【24h】

Aqua mediated synthesis of 2-amino-6-benzothiazol-2-ylsulfanyl-chromenes and its in vitro study, explanation of the structure-activity relationships (SARs) as antibacterial agent.

机译：Aqua介导的2-氨基-6-苯并噻唑-2-基硫烷基-色烯的合成及其体外研究，解释了作为抗菌剂的构效关系（SARs）。

获取原文

获取原文并翻译 | 示例

掌桥外文数据库（机构版） >>

开具论文收录证明 >>

文献代查 >>

页面导航

摘要
著录项
相似文献
相关主题

摘要

Multi-component reaction (MCR) involves coupling of p-bromophenol with 2-Benzothiazolethiol, malononitrile and substituted aldehydes in aqueous K(2)CO(3) as green base to synthesize 2-amino-6-benzothiazol-2-ylsulfanyl-chromenes. This multi-component reaction thus offers a higher yield and versatility in the preparation of densely functionalized oxygen heterocycles. The newly synthesized compounds were screened for their antibacterial activities against positive and gram negative pathogenic strains to bacteria. SAR analysis was performed to explore comprehensive structure-activity relationships and a statistically reliable model to explain their antibacterial activities.

机译：多组分反应（MCR）涉及将对溴苯酚与2-苯并噻唑硫醇，丙二腈和取代的醛在水性K（2）CO（3）中作为绿色碱合成2-氨基-6-苯并噻唑-2-基硫烷基-色胺。因此，该多组分反应在制备致密官能化的氧杂环化合物中提供了更高的产率和多功能性。筛选新合成的化合物对细菌的阳性和革兰氏阴性致病菌株的抗菌活性。进行SAR分析以探索全面的构效关系，并建立统计可靠的模型来解释其抗菌活性。

著录项

来源
《European Journal of Medicinal Chemistry: Chimie Therapeutique》 |2010年第11期|共8页
作者
Kidwai M; Poddar R; Bhardwaj S; Singh S; Luthra PM;
展开▼
作者单位

展开▼
收录信息
原文格式 PDF
正文语种 eng
中图分类药学;
关键词

相似文献

外文文献
中文文献
专利

1. Aqua mediated synthesis of 2-amino-6-benzothiazol-2-ylsulfanyl-chromenes and its in vitro study, explanation of the structure-activity relationships (SARs) as antibacterial agent. [J] . Kidwai M, Poddar R, Bhardwaj S, European Journal of Medicinal Chemistry: Chimie Therapeutique . 2010,第11期

机译：Aqua介导的2-氨基-6-苯并噻唑-2-基硫烷基-色烯的合成及其体外研究，解释了作为抗菌剂的构效关系（SARs）。
2. Aqua mediated synthesis of 2-amino-6-benzothiazol-2-ylsulfanyl-chromenes and its in vitro study, explanation of the structure-activity relationships (SARs) as antibacterial agent. [J] . Kidwai M, Poddar R, Bhardwaj S, European Journal of Medicinal Chemistry: Chimie Therapeutique . 2010,第11期

机译：Aqua介导的2-氨基-6-苯并噻唑-2-烯磺酰基 - 结合的合成及其体外研究，对结构 - 活性关系（SARS）作为抗菌剂的解释。
3. Aqua mediated synthesis of 2-amino-6-benzothiazol-2-ylsulfanyl-chromenes and its in vitro study, explanation of the structure-activity relationships (SARs) as antibacterial agent. [J] . Kidwai M, Poddar R, Bhardwaj S, European Journal of Medicinal Chemistry: Chimie Therapeutique . 2010,第11期

机译：Aqua介导的2-氨基-6-苯并噻唑-2-烯磺酰基 - 结合的合成及其体外研究，对结构 - 活性关系（SARS）作为抗菌剂的解释。
4. Structure-activity relationship study on Bac7(l-35),a synthetic fragment of the Pro-rich antibacterial peptide Bac7 [C] . Monica Benincasa, Elena Podda, Marco Scocchi International Peptide Symposium;European Peptide Symposium . 2005

机译：Bac7（L-35）的结构 - 活性关系研究，富含富含抗菌肽Bac7的合成片段
5. Synthesis of side chain-modified iodothyronines. Synthesis and structure-activity relationships (SARS) of galanthamine derivatives. Total synthesis of (+)-valyldetoxinine. Synthesis and mechanism of cyclic acetal and ketal formation in pentono-1,4-lactones. [D] . Han, So-Yeop. 1992

机译：侧链修饰的碘甲状腺素的合成。加兰他敏衍生物的合成及其构效关系（SARS）。（+）-Valyldetoxinine的全合成。戊通-1,4-内酯中环状缩醛和缩酮的合成及其机理。
6. Synthesis Structure-Activity Relationships (SAR) and in Silico Studies of Coumarin Derivatives with Antifungal Activity [O] . Rodrigo S. A. de Araújo, Felipe Q. S. Guerra, Edeltrudes de O. Lima, 2013

机译：具有抗真菌活性的香豆素衍生物的合成构效关系（SAR）和计算机模拟研究
7. Structure-Activity Relationship (SAR) Studies on Oxazolidinone Antibacterial Agents. 3. Synthesis and Evaluation of 5-Thiocarbamate Oxazolidinones. [O] . Ryukou TOKUYAMA, Yoshiei TAKAHASHI, Yayoi TOMITA, 2001

机译：恶唑烷酮抗菌剂的结构 - 活性关系（SAR）研究。 3. 5-硫代氨基甲酸盐氧酰胺的合成和评价。

Aqua mediated synthesis of 2-amino-6-benzothiazol-2-ylsulfanyl-chromenes and its in vitro study, explanation of the structure-activity relationships (SARs) as antibacterial agent.

摘要

著录项

相似文献

相关主题

期刊订阅