Aqua mediated synthesis of 2-amino-6-benzothiazol-2-ylsulfanyl-chromenes and its in vitro study, explanation of the structure-activity relationships (SARs) as antibacterial agent.

Kidwai M; Poddar R; Bhardwaj S; Singh S; Luthra PM

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Aqua mediated synthesis of 2-amino-6-benzothiazol-2-ylsulfanyl-chromenes and its in vitro study, explanation of the structure-activity relationships (SARs) as antibacterial agent.

机译：Aqua介导的2-氨基-6-苯并噻唑-2-烯磺酰基 - 结合的合成及其体外研究，对结构 - 活性关系（SARS）作为抗菌剂的解释。

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Multi-component reaction (MCR) involves coupling of p-bromophenol with 2-Benzothiazolethiol, malononitrile and substituted aldehydes in aqueous K(2)CO(3) as green base to synthesize 2-amino-6-benzothiazol-2-ylsulfanyl-chromenes. This multi-component reaction thus offers a higher yield and versatility in the preparation of densely functionalized oxygen heterocycles. The newly synthesized compounds were screened for their antibacterial activities against positive and gram negative pathogenic strains to bacteria. SAR analysis was performed to explore comprehensive structure-activity relationships and a statistically reliable model to explain their antibacterial activities.

机译：多组分反应（MCR）涉及对苯并噻唑硫醇，k（2）CO（3）中的苯噻唑硫醇，丙二腈和取代的醛作为绿基，以合成2-氨基-6-苯并噻唑-2-基磺酰基 - 结合。因此，这种多组分反应在制备密集的官能化氧杂环中提供更高的产量和多功能性。将新合成的化合物筛选对它们的抗菌活性，与阳性和革兰氏阴性致病菌菌株到细菌。进行SAR分析以探索综合结构活动关系和统计上可靠的模型来解释其抗菌活动。

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《European Journal of Medicinal Chemistry: Chimie Therapeutique》 |2010年第11期|共8页
作者
Kidwai M; Poddar R; Bhardwaj S; Singh S; Luthra PM;
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Green Research Laboratory Department of Chemistry University of Delhi New Delhi 110007 India.;

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正文语种 eng
中图分类药学;
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1. Aqua mediated synthesis of 2-amino-6-benzothiazol-2-ylsulfanyl-chromenes and its in vitro study, explanation of the structure-activity relationships (SARs) as antibacterial agent. [J] . Kidwai M, Poddar R, Bhardwaj S, European Journal of Medicinal Chemistry: Chimie Therapeutique . 2010,第11期

机译：Aqua介导的2-氨基-6-苯并噻唑-2-基硫烷基-色烯的合成及其体外研究，解释了作为抗菌剂的构效关系（SARs）。
2. Aqua mediated synthesis of 2-amino-6-benzothiazol-2-ylsulfanyl-chromenes and its in vitro study, explanation of the structure-activity relationships (SARs) as antibacterial agent. [J] . Kidwai M, Poddar R, Bhardwaj S, European Journal of Medicinal Chemistry: Chimie Therapeutique . 2010,第11期

机译：Aqua介导的2-氨基-6-苯并噻唑-2-烯磺酰基 - 结合的合成及其体外研究，对结构 - 活性关系（SARS）作为抗菌剂的解释。
3. Aqua mediated synthesis of 2-amino-6-benzothiazol-2-ylsulfanyl-chromenes and its in vitro study, explanation of the structure-activity relationships (SARs) as antibacterial agent. [J] . Kidwai M, Poddar R, Bhardwaj S, European Journal of Medicinal Chemistry: Chimie Therapeutique . 2010,第11期

机译：Aqua介导的2-氨基-6-苯并噻唑-2-烯磺酰基 - 结合的合成及其体外研究，对结构 - 活性关系（SARS）作为抗菌剂的解释。
4. Structure-activity relationship study on Bac7(l-35),a synthetic fragment of the Pro-rich antibacterial peptide Bac7 [C] . Monica Benincasa, Elena Podda, Marco Scocchi International Peptide Symposium;European Peptide Symposium . 2005

机译：Bac7（L-35）的结构 - 活性关系研究，富含富含抗菌肽Bac7的合成片段
5. Synthesis of side chain-modified iodothyronines. Synthesis and structure-activity relationships (SARS) of galanthamine derivatives. Total synthesis of (+)-valyldetoxinine. Synthesis and mechanism of cyclic acetal and ketal formation in pentono-1,4-lactones. [D] . Han, So-Yeop. 1992

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机译：恶唑烷酮抗菌剂的结构 - 活性关系（SAR）研究。 3. 5-硫代氨基甲酸盐氧酰胺的合成和评价。

Aqua mediated synthesis of 2-amino-6-benzothiazol-2-ylsulfanyl-chromenes and its in vitro study, explanation of the structure-activity relationships (SARs) as antibacterial agent.

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