Synthesis, antiproliferative activity and inhibition of tubulin polymerization by anthracenone-based oxime derivatives.

Surkau G; Bohm KJ; Muller K; Prinz H

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Synthesis, antiproliferative activity and inhibition of tubulin polymerization by anthracenone-based oxime derivatives.

机译：蒽醌基肟衍生物的合成，抗增殖活性和对微管蛋白聚合的抑制作用。

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A series of anthracenone-based oxime ethers and -esters were synthesized in order to evaluate their antiproliferative activity. Several investigated compounds displayed strong antiproliferative activity against K562 leukemia cells and proved to be strong inhibitors of tubulin polymerization. In this context, anthracenone-based oxime ethers and -esters are considered to contribute to the development of novel antiproliferative drugs, based on tubulin interaction.

机译：为了评估它们的抗增殖活性，合成了一系列基于蒽醌的肟醚和酯。几种研究过的化合物显示出对K562白血病细胞的强抗增殖活性，并被证明是微管蛋白聚合的强抑制剂。在这种情况下，基于微管蛋白的相互作用，基于蒽环酮的肟醚和酯被认为有助于新型抗增殖药的开发。

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《European Journal of Medicinal Chemistry: Chimie Therapeutique》 |2010年第8期|共11页
作者
Surkau G; Bohm KJ; Muller K; Prinz H;
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1. Synthesis, antiproliferative activity and inhibition of tubulin polymerization by anthracenone-based oxime derivatives. [J] . Surkau G, Bohm KJ, Muller K, European Journal of Medicinal Chemistry: Chimie Therapeutique . 2010,第8期

机译：蒽醌基肟衍生物的合成，抗增殖活性和对微管蛋白聚合的抑制作用。
2. Pyrazole-oxadiazole conjugates: synthesis, antiproliferative activity and inhibition of tubulin polymerization [J] . Ahmed Kamal, Anver Basha Shaik, Sowjanya Polepalli, Organic & biomolecular chemistry . 2014,第40期

机译：吡唑-恶二唑结合物：合成，抗增殖活性和抑制微管蛋白聚合
3. Novel 2-Substituted Quinolin-4-yl-benzenesulfonate Derivatives: Synthesis, Antiproliferative Activity, and Inhibition of Cellular Tubulin Polymerization [J] . Rajesh Kakadiya, Yi-Chen Wu, Huajin Dong ChemMedChem . 2011,第6期

机译：新型2-取代的喹啉-4-基-苯磺酸衍生物：合成，抗增殖活性和抑制细胞微管蛋白聚合。
4. Design, Synthesis and Anti-fungal Activity of the Oleanic Acid Oxime Esters and Oxime Ethers [C] . Hanqing Zhao, Minjie Zhou, Jianjun Zhang, Proceedings of 4th international symposium on pesticides and environmental safety amp; 5th pan Pacific confernce on pesticide science amp; 8th international workshop on crop protection chemistry and regulatory harmonization . 2012

机译：齐墩果酸肟酯和肟醚的设计，合成及抗真菌活性
5. Total syntheses of (9R, 10S)-epi-ustiloxin analogues to probe the inhibition of tubulin polymerization and investigations toward ustiloxin A. [D] . Evans, Cory Dale. 2007

机译：（9R，10S）-表-ustiloxin类似物的总合成以探测微管蛋白聚合的抑制作用和对ustiloxin A的研究。
6. (Z)-1-Aryl-3-arylamino-2-propen-1-ones Highly Active Stimulators of Tubulin Polymerization: Synthesis Structure Activity Relationship (SAR) Tubulin Polymerization and Cell Growth Inhibition Studies [O] . M.V. Ramana Reddy, Balaiah Akula, Stephen C Cosenza, -1

机译：（Z）-1-芳基-3-芳基氨基-2-丙烯-1-酮微管蛋白聚合的高活性刺激物的合成结构活性关系（saR）微管蛋白聚合和细胞生长抑制研究
7. 9-Benzylidene-naphtho2, 3-bthiophen-4-ones as Novel Antimicrotubule AgentssSynthesis, Antiproliferative Activity, and Inhibition of Tubulin Polymerization [O] . -1

机译：9-苄基 - 萘2,3-B噻吩-4-作为新型抗微药剂剂的合成，抗增殖活性和管蛋白聚合的抑制作用

Synthesis, antiproliferative activity and inhibition of tubulin polymerization by anthracenone-based oxime derivatives.

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