Synthesis and antitumor activity of liquiritigenin thiosemicarbazone derivatives.

Hu K; Yang ZH; Pan SS; Xu HJ; Ren J

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Synthesis and antitumor activity of liquiritigenin thiosemicarbazone derivatives.

机译：Liquiritigenin thiosemicarbazone衍生物的合成及其抗肿瘤活性。

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In an attempt to develop potent and selective antitumor agents, a series of liquiritigenin thiosemicarbazone derivatives were designed and synthesized. The cytotoxicities of these compounds were evaluated in vitro against K562, DU-145, SGC-7901, HCT-116 and Hela cell lines. The pharmacological results showed that most of the prepared compounds displayed excellent selective cytotoxicity toward K562 and DU-145 cells. From the structure-activity relationships we may conclude that the introduction of a thiosemicarbazone functional group at the 4-position in the skeleton of liquiritigenin is associated with an increase in cytotoxicity.

机译：为了开发有效的和选择性的抗肿瘤药，设计并合成了一系列的liquiritigenin thiosemicarbazone衍生物。在体外评估了这些化合物对K562，DU-145，SGC-7901，HCT-116和Hela细胞系的细胞毒性。药理结果表明，大多数制备的化合物对K562和DU-145细胞具有优异的选择性细胞毒性。从结构-活性关系中，我们可以得出结论，在Liquiritigenin骨架的4位上引入硫半脲官能团与细胞毒性增加有关。

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《European Journal of Medicinal Chemistry: Chimie Therapeutique》 |2010年第8期|共6页
作者
Hu K; Yang ZH; Pan SS; Xu HJ; Ren J;
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正文语种 eng
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Synthesis and antitumor activity of liquiritigenin thiosemicarbazone derivatives.

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