Studying synergism of methyl linked cyclohexyl thiophenes with triazole: synthesis and their cdk5/p25 inhibition activity.

Shiradkar M; Thomas J; Kanase V; Dighe R

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Studying synergism of methyl linked cyclohexyl thiophenes with triazole: synthesis and their cdk5/p25 inhibition activity.

机译：研究甲基连接的环己基噻吩与三唑的协同作用：合成及其对cdk5 / p25的抑制活性。

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A novel clubbed triazolyl thiophene series of cdk5/p25 inhibitors, potentially useful for the treatment of Alzheimer's disease, is disclosed. Evaluation of the SAR of substitution within these series has allowed the identification of a range of compounds which significantly reduce brain cdk5/p25 and thus have potential as possible treatments for Alzheimer's disease.

机译：公开了一种新颖的棒状三唑基噻吩系列的cdk5 / p25抑制剂，其潜在可用于治疗阿尔茨海默氏病。通过评估这些系列中的替代SAR，可以鉴定出一系列化合物，这些化合物可显着降低脑cdk5 / p25，因此具有潜在治疗阿尔茨海默氏病的潜力。

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《European Journal of Medicinal Chemistry: Chimie Therapeutique》 |2011年第6期|共9页
作者
Shiradkar M; Thomas J; Kanase V; Dighe R;
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正文语种 eng
中图分类药学;
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1. Studying synergism of methyl linked cyclohexyl thiophenes with triazole: synthesis and their cdk5/p25 inhibition activity. [J] . Shiradkar M, Thomas J, Kanase V, European Journal of Medicinal Chemistry: Chimie Therapeutique . 2011,第6期

机译：研究甲基连接的环己基噻吩与三唑的协同作用：合成及其对cdk5 / p25的抑制活性。
2. Synthesis and structure-activity relationship of 4-(1,3-benzothiazol-2-yl)- thiophene-2-sulfonamides as cyclin-dependent kinase 5 (cdk5)/p25 inhibitors [J] . Malmstr?mJ., ViklundJ., SlivoC., Bioorganic and Medicinal Chemistry Letters . 2012,第18期

机译：4-（1,3-苯并噻唑-2-基）-噻吩-2-磺酰胺作为细胞周期蛋白依赖性激酶5（cdk5）/ p25抑制剂的合成及其构效关系
3. Specific inhibition of p25/Cdk5 activity by the Cdk5 inhibitory peptide reduces neurodegeneration in vivo [J] . The Journal of Neuroscience: The Official Journal of the Society for Neuroscience . 2013,第1期

机译：Cdk5抑制肽对p25 / Cdk5活性的特异性抑制可减少体内神经变性
4. The Synthesis of Ethyl-1-Benzyl-5-Methyl-1H-1,2,3-Triazoles-4-Carboxylate Using Microwave Assisted Organic Synthesis Method and Determination of Its Corrosion Inhibition Activity on Carbon Steel [C] . Rayyane Mazaya Syifa Insani, Deana Wahyuningrum, Bunbun Bundjali Materials Research Society of Indonesia Meeting . 2015

机译：使用微波辅助有机合成方法合成乙基-1-苄基-5-甲基-1H-1,2,3-三唑-4-羧酸盐及其对碳钢腐蚀抑制活性的测定
5. Design and synthesis of novel benzimidazoles and aminothiazoles as small molecule inhibitors of CDK5/p25 [D] . Jain, Prashi 2012

机译：新型苯并咪唑和氨基噻唑作为CDK5 / p25小分子抑制剂的设计与合成
6. Specific Inhibition of p25/Cdk5 Activity by the Cdk5 Inhibitory Peptide Reduces Neurodegeneration In Vivo [O] . Jeyapriya Raja Sundaram, Charlene Priscilla Poore, Noor Hazim Bin Sulaimee, 2013

机译：Cdk5抑制肽对p25 / Cdk5活性的特异性抑制可降低体内神经变性。
7. Specific inhibition of p25/Cdk5 activity by the Cdk5 inhibitory peptide reduces neurodegeneration in vivo [O] . Sundaram, Jeyapriya Raja, Poore, Charlene Priscilla, Bin Sulaimee, Noor Hazim, 2013

机译：Cdk5抑制肽对p25 / Cdk5活性的特异性抑制可减少体内神经变性

Studying synergism of methyl linked cyclohexyl thiophenes with triazole: synthesis and their cdk5/p25 inhibition activity.

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