Synthesis and study of 2-amino-7-bromofluorenes modified with nitroxides and their precursors as dual anti-amyloid and antioxidant active compounds.

Kalai T; Petrlova J; Balog M; Aung HH; Voss JC; Hideg K

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Synthesis and study of 2-amino-7-bromofluorenes modified with nitroxides and their precursors as dual anti-amyloid and antioxidant active compounds.

机译：氮氧化物改性的2-氨基-7-溴芴及其前体作为双重抗淀粉样蛋白和抗氧化剂活性化合物的合成和研究。

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A series of 2-aminofluorenes N-alkylated with nitroxides or their precursors were synthesized. The new compounds were tested on hydroxyl radical and peroxyl radical scavenging ability and inflammatory assay on the endothelial brain cells. In agreement with ROS scavenging ability the same compound 7-bromo-N -[(1-Oxyl-2,2,6,6-tetramethyl-1,2,3,6-tetrahydropyridine-4yl)methyl]-9H-fluoren-2 -amine (3b) and its hydroxylamine salt (3b/OH/HCl) showed the anti-inflammatory property on the endothelial brain cells.

机译：合成了一系列用氮氧化物或其前体N-烷基化的2-氨基芴。测试了这些新化合物在内皮脑细胞上的清除羟自由基和过氧自由基的能力以及炎性实验。与ROS清除能力一致，相同的化合物7-溴-N-[（1-氧基-2,2,6,6-四甲基-1,2,3,6-四氢吡啶-4基）甲基] -9H-氟- 2-胺（3b）及其羟胺盐（3b / OH / HCl）对内皮脑细胞具有抗炎作用。

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《European Journal of Medicinal Chemistry: Chimie Therapeutique》 |2011年第4期|共8页
作者
Kalai T; Petrlova J; Balog M; Aung HH; Voss JC; Hideg K;
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1. Synthesis and study of 2-amino-7-bromofluorenes modified with nitroxides and their precursors as dual anti-amyloid and antioxidant active compounds. [J] . Kalai T, Petrlova J, Balog M, European Journal of Medicinal Chemistry: Chimie Therapeutique . 2011,第4期

机译：氮氧化物改性的2-氨基-7-溴芴及其前体作为双重抗淀粉样蛋白和抗氧化剂活性化合物的合成和研究。
2. Synthesis and functional survey of new Tacrine analogs modified with nitroxides or their precursors [J] . Tamas Kalai, Robin Altman, Izumi Maezawa, European Journal of Medicinal Chemistry: Chimie Therapeutique . 2014,第Null期

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3. Structure-activity studies on the protection of Trimetazidine derivatives modified with nitroxides and their precursors from myocardial ischemia-reperfusion injury. [J] . Kalai T, Khan M, Balog M, Bioorganic and medicinal chemistry . 2006,第16期

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4. Dual phluorophore-nitroxides as a tool for analysis of antioxidants, nitric oxide and superoxide in biological liquids and tissues [C] . LIKHTENSHTEIN GERTZ I Advances in sensors, signals and materials . 2010

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5. Part 1. Relative antioxidant efficiency of synthetic and natural compounds. Part 2. Synthesis, characterization of cysteine oligopeptides and assessment of their antioxidant activity [D] . Li, Chunyu 2005

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6. Synthesis and study of 2-amino- 7-bromofluorenes modified with nitroxides and their precursors as dual anti-amyloid and antioxidant active compounds [O] . Tamás Kálai, Jitka Petrlova, Mária Balog, -1

机译：用硝基氧化物改性2-氨基-7-溴氟苯及其前体作为双抗淀粉样蛋白和抗氧化活性化合物的合成及研究
7. Synthesis and study of 2-amino-7-bromofluorenes modified with nitroxides and their precursors as dual anti-amyloid and antioxidant active compounds [O] . Tamás Kálai, Jitka Petrlova, Mária Balog, 2011

机译：用硝基氧化物及其前体改性二氨基-7-溴氟苯的合成与研究，作为双抗淀粉样蛋白和抗氧化活性化合物
8. Tetraalkyldiarsines as Potential Precursors for Electronic Materials: Synthesis and Characterization of Various Iso-Propyl Arsenic Compounds. [R] . Brough, L. F., Gang, L., Lipkovich, M. A., 1994

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Synthesis and study of 2-amino-7-bromofluorenes modified with nitroxides and their precursors as dual anti-amyloid and antioxidant active compounds.

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