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首页> 外文期刊>European Journal of Medicinal Chemistry: Chimie Therapeutique >Advantages of cocrystallization in the field of solid-state pharmaceutical chemistry: l-Proline and MnCl(2).
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Advantages of cocrystallization in the field of solid-state pharmaceutical chemistry: l-Proline and MnCl(2).

机译：固态药物化学领域中共结晶的优势：l-脯氨酸和MnCl（2）。

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摘要

Cocrystallization (formation of a "cocrystal") is an emerging method to optimize physico-chemical properties of pharmaceutically active compounds. One elegant technique used to obtain such cocrystals is grinding the components together, either alone or in the presence of a small amount of solvent (so called solvent-drop grinding). Dry grinding has been used here to obtain cocrystals (actually a hydrated salt) of l-Proline and MnCl(2). In that context, a new crystalline structure of a multicomponent molecular complex composed of l-Proline and MnCl(2) is here reported. The complex was characterized by powder and single-crystal X-ray diffraction and differential scanning calorimetry. This study underlines the interest of grinding as a method to synthesize original solid-state complexes. It also emphasizes the advantage of combining calorimetric and X-ray diffraction to characterize the newly formed solids. Finally, our work provides structural basis for the role that l-Proline can play within multicomponent solid-state molecular complexes, in particular as a potential cocrystal former acting by both ionic and H-bond interactions when combined to molecules of pharmaceutical interest.
机译：共结晶（“共晶体”的形成）是优化药物活性化合物的物理化学性质的新兴方法。用于获得此类共晶的一种精巧技术是单独或在少量溶剂存在下将组分一起研磨（所谓的溶剂滴磨）。干磨在这里已用于获得l-脯氨酸和MnCl（2）的共晶体（实际上是水合盐）。在这种情况下，这里报道了由l-脯氨酸和MnCl（2）组成的多组分分子复合物的新晶体结构。该复合物通过粉末和单晶X射线衍射以及差示扫描量热法进行表征。这项研究强调了研磨作为合成原始固态配合物的一种方法的兴趣。它还强调了将量热法和X射线衍射相结合来表征新形成的固体的优势。最后，我们的工作为l-脯氨酸在多组分固态分子复合物中的作用提供了结构基础，尤其是当与药物分子结合时，通过离子和氢键相互作用而发挥作用的潜在共晶形成剂。

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