Synthesis and antimicrobial evaluation of new benzofuran derivatives.

Jiang X; Liu W; Zhang W; Jiang F; Gao Z; Zhuang H; Fu L

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Synthesis and antimicrobial evaluation of new benzofuran derivatives.

机译：新的苯并呋喃衍生物的合成和抗菌评估。

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Thirteen compounds, based on benzofuran skeleton bearing aryl substituents at its C-3 position through methanone linker, were synthesized and screened for their antibacterial and antifungal activities against four bacteria Escherichia coli, Staphylococcus aureus, Methicillin-resistant S.aureus, Bacillus subtilis, and a fungus Candida albicans. Four hydrophobic benzofuran analogs were found to exhibit favorable antibacterial activities (MIC(80) = 0.39-3.12 mug/mL), which were better than the control drugs.

机译：合成了13种化合物，这些化合物基于通过甲酮连接子在C-3位带有芳基取代基的苯并呋喃骨架，并针对四种细菌大肠杆菌，金黄色葡萄球菌，耐甲氧西林金黄色葡萄球菌，枯草芽孢杆菌和一种白色念珠菌。发现四个疏水的苯并呋喃类似物表现出良好的抗菌活性（MIC（80）= 0.39-3.12 mug / mL），优于对照药物。

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《European Journal of Medicinal Chemistry: Chimie Therapeutique》 |2011年第8期|共5页
作者
Jiang X; Liu W; Zhang W; Jiang F; Gao Z; Zhuang H; Fu L;
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正文语种 eng
中图分类药学;
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Synthesis and antimicrobial evaluation of new benzofuran derivatives.

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