Convenient synthesis and antimicrobial activity of new 3-substituted 5-(benzofuran-2-yl)-pyrazole derivatives.

Abdel-Wahab BF; Abdel-Aziz HA; Ahmed EM

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Convenient synthesis and antimicrobial activity of new 3-substituted 5-(benzofuran-2-yl)-pyrazole derivatives.

机译：新型3取代的5-（苯并呋喃-2-基）-吡唑衍生物的便捷合成和抗菌活性。

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The reaction of ethyl 4-(benzofuran-2-yl)-2,4-dioxobutanoate 2 with two moles of hydrazine hydrate afforded 5-(benzofuran-2-yl)-1H-pyrazole-3-carbohydrazide 4a, while its reaction with equimolar amount of phenylhydrazine gave ester 3b which then converted to 5-(benzofuran-2-yl)-1-phenyl-1H-pyrazole-3-carbohydrazide 4b. Various new compounds such as imides 5 and 6, acyl hydrazones 7 and 8, bi-pyrazoles 9-12, and 1,3-thiazole derivatives 14 and 15 were prepared from carbohydrazide derivatives 4a, b. The new compounds are tested for their antimicrobial activity. Compounds 2, 5, 7, and 8 showed antifungal activities against C. albicans. Also, compounds 2, 6, 8, and 15 showed antibacterial activities.

机译：4-（苯并呋喃-2-基）-2,4-二氧代丁酸乙酯2与两摩尔水合肼的反应制得5-（苯并呋喃-2-基）-1H-吡唑-3-碳酰肼4a，同时与等摩尔量的苯肼得到酯3b，然后将其转化为5-（苯并呋喃-2-基）-1-苯基-1H-吡唑-3-碳酰肼4b。由碳酰肼衍生物4a，b制备了各种新化合物，例如酰亚胺5和6，酰基hydr7和8，联吡唑9-12和1，3-噻唑衍生物14和15。测试了新化合物的抗菌活性。化合物2、5、7和8对白念珠菌具有抗真菌活性。同样，化合物2、6、8和15显示出抗菌活性。

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《Archiv der Pharmazie》 |2008年第11期|共6页
作者
Abdel-Wahab BF; Abdel-Aziz HA; Ahmed EM;
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正文语种 eng
中图分类药学;
关键词
Anti-Bacterial Agents; Antifungal Agents; Butyric Acids; Candida albicans; 抗真菌药; 丁酸类; 念珠菌; 白色; 肼类; 微生物敏感性试验; 吡唑类; 构效关系;

机译：Anti-Bacterial Agents;Antifungal Agents;Butyric Acids;Candida albicans;抗真菌药;丁酸类;念珠菌;白色;肼类;微生物敏感性试验;吡唑类;构效关系;

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1. Convenient synthesis and antimicrobial activity of new 3-substituted 5-(benzofuran-2-yl)-pyrazole derivatives. [J] . Abdel-Wahab BF, Abdel-Aziz HA, Ahmed EM Archiv der Pharmazie . 2008,第11期

机译：新型3取代的5-（苯并呋喃-2-基）-吡唑衍生物的便捷合成和抗菌活性。
2. Synthesis, antitumor activity and molecular docking study of novel benzofuran-2-yl pyrazole pyrimidine derivatives. [J] . El Zahar MI, Adb El Karim SS, Haiba ME, Acta Poloniae Pharmaceutica: Durg Research . 2011,第3期

机译：新型苯并呋喃-2-基吡唑嘧啶衍生物的合成，抗肿瘤活性和分子对接研究。
3. Synthesis and antimicrobial evaluation of 1-(benzofuran-2-yl)-4-nitro-3-arylbutan-1-ones and 3-(benzofuran-2-yl)-4,5-dihydro-5-aryl-1-(4-(aryl)-1,3-thiazol-2-yl)-1H-pyrazoles. [J] . Abdel Aziz Hatem A, Ahmed Essam M European Journal of Medicinal Chemistry: Chimie Therapeutique . 2009,第6期

机译：1-（苯并呋喃-2-基）-4-硝基-3-芳基丁-1-酮和3-（苯并呋喃-2-基）-4,5-二氢-5-芳基-1-（）的合成及抗菌性能4-（芳基）-1,3-噻唑-2-基）-1H-吡唑。
4. Synthesis,structural elucidation and antimicrobial activities of 5-(3-nitrophenyllazo)-6-aminouracil and its complexes with some transition metal ions [C] . Z M Zaki, S M Abbas, H A Dessoukii International Conference on Advanced Sciences . 2018

机译：5-（3-硝基苯齐噻唑）-6-Aminouracil的合成，结构阐明和抗微生物活性及其络合物与一些过渡金属离子
5. Synthesis of Novel Thiazole and Pyrazole Derivatives as Antimicrobial and Anticancer Agents [D] . Khan, Md Mahbub Kabir. 2020

机译：新型噻唑和吡唑衍生物作为抗微生物和抗癌剂的合成
6. Utility of 5-(furan-2-yl)-3-(p-tolyl)-45-dihydro-1H-pyrazole-1-carbothioamide in the synthesis of heterocyclic compounds with antimicrobial activity [O] . Abdou O. Abdelhamid, Ibrahim E. El Sayed, Yasser H. Zaki, 2019

机译：5-（呋喃-2-基）-3-（对甲苯基）-45-二氢-1H-吡唑-1-碳硫酰胺在具有抗菌活性的杂环化合物合成中的应用
7. Synthesis, structural characterisation and biological activity of Zn(II) and Pd(II) complexes of 3-substituted 5-(2'-pyridyl)-1,4-benzodiazepin-2-one derivatives. [O] . Visnjevac, A., Tusek-Bozic, L., Majeric-Elenkov, M., 2002

机译：3-取代的5-（2'-吡啶基）-1,4-苯并二氮杂-2-酮衍生物的Zn（II）和pd（II）络合物的合成，结构表征和生物活性。

Convenient synthesis and antimicrobial activity of new 3-substituted 5-(benzofuran-2-yl)-pyrazole derivatives.

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