Synthesis and antibacterial activity of novel ketolides with 11,12-sulfur contained aryl alkyl side chains.

Chen XZ; Xu P; Liu L; Zheng D; Lei PS

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Synthesis and antibacterial activity of novel ketolides with 11,12-sulfur contained aryl alkyl side chains.

机译：含11,12-硫的新型酮醇的合成及其抗菌活性。

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A novel series of ketolides with 11,12-sulfur contained aryl alkyl side chains were synthesized and evaluated for their antibacterial activity. These ketolides exhibited potent activity against key macrolide sensitive and resistant respiratory pathogens. The newly synthesized 9a, 9e, 9k and 9n showed a similar antimicrobial spectrum and comparable activity to telithromycin, the commercial ketolide antibacterial.

机译：合成了一系列新的具有11,12-硫的芳基烷基侧链的酮醇化物，并对其抗菌活性进行了评估。这些酮醇化物对主要的大环内酯类敏感和耐药呼吸道病原体表现出有效的活性。新合成的9a，9e，9k和9n表现出相似的抗菌谱，并具有与商业化的酮内酯抗菌剂telithromycin相当的活性。

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《European Journal of Medicinal Chemistry: Chimie Therapeutique》 |2011年第1期|共10页
作者
Chen XZ; Xu P; Liu L; Zheng D; Lei PS;
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正文语种 eng
中图分类药学;
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1. Synthesis and antibacterial activity of novel ketolides with 11,12-sulfur contained aryl alkyl side chains. [J] . Chen XZ, Xu P, Liu L, European Journal of Medicinal Chemistry: Chimie Therapeutique . 2011,第1期

机译：含11,12-硫的新型酮醇的合成及其抗菌活性。
2. Synthesis, antibacterial activity and docking of 14-membered 9-O-(3-arylalkyl) oxime 11,12-cyclic carbonate ketolides [J] . LiangJ.-H., AnK., LvW., European Journal of Medicinal Chemistry: Chimie Therapeutique . 2013,第Null期

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3. Synthesis and antibacterial activity of 6-O-arylpropargyl-9-oxime-11,12-carbamate ketolides. [J] . Beebe X, Yang F, Bui MH, Bioorganic and Medicinal Chemistry Letters . 2004,第10期

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Synthesis and antibacterial activity of novel ketolides with 11,12-sulfur contained aryl alkyl side chains.

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