Piperazine-linked bisbenzamidines: a novel class of antileishmanial agents.

Mayence A; Vanden Eynde JJ; LeCour L Jr; Walker LA; Tekwani BL; Huang TL

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Piperazine-linked bisbenzamidines: a novel class of antileishmanial agents.

机译：哌嗪连接的双苯甲m：一类新的抗疟药。

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A series of 13 1,4-diarylpiperazines has been prepared, evaluated for antileishmanial activity and their binding affinity to DNA was measured. Among these compounds, 1,4-bis[4-(1H-benzimidazol-2-yl)phenyl]piperazine (14) emerged as the most active compound with an IC(50) value of 0.41 microM which is about sevenfold more potent than pentamidine.

机译：制备了一系列13种1,4-二芳基哌嗪，评估了其抗疟疾活性，并测定了它们与DNA的结合亲和力。在这些化合物中，1,4-双[4-（1H-苯并咪唑-2-基）苯基]哌嗪（14）成为活性最高的化合物，IC（50）值为0.41 microM，比有效化合物高约七倍。喷他idine

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来源
《European Journal of Medicinal Chemistry: Chimie Therapeutique》 |2004年第6期|共7页
作者
Mayence A; Vanden Eynde JJ; LeCour L Jr; Walker LA; Tekwani BL; Huang TL;
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正文语种 eng
中图分类基础医学;
关键词
piperazine; novel; binding; Pentamidine; Inspiratory Capacity; 喷他脒; 吸气量;

机译：piperazine;novel;binding;Pentamidine;Inspiratory Capacity;喷他脒;吸气量;

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1. Piperazine-linked bisbenzamidines: a novel class of antileishmanial agents. [J] . Mayence A, Vanden Eynde JJ, LeCour L Jr, European Journal of Medicinal Chemistry: Chimie Therapeutique . 2004,第6期

机译：哌嗪连接的双苯甲m：一类新的抗疟药。
2. Highly Active Anti-Pneumocystis carinii Compounds in a Library of Novel Piperazine-Linked Bisbenzamidines and Related Compounds. [J] . Cushion MT, Collins MS, Vanden Eynde JJ, Antimicrobial agents and chemotherapy. . 2004,第11期

机译：新型哌嗪连接的双苯甲m和相关化合物库中的高活性抗卡氏肺孢子虫化合物。
3. Triazolopyridyl ketones as a novel class of antileishmanial agents. DNA binding and BSA interaction [J] . AdamR., Bilbao-RamosP., López-MolinaS., Bioorganic and medicinal chemistry . 2014,第15期

机译：三唑并吡啶基酮是一类新的抗霉菌剂。 DNA结合和BSA相互作用
4. N-(2-HYDROXYPROPYL)METHACRYLAMIDE COPOLYMER-8-AMINOQUINOLINE CONJUGATES FOR TARGETED ANTILEISHMANIAL DRUG DELIVERY [C] . A. Nan, D. Nanayakkara, L. A. Walker, International symposium on controlled release of bioactive materials;Consumer diversified products conference . 2001

机译：N-（2-羟基丙基）甲基丙烯酰胺共聚物-8-氨基喹啉偶联物，用于靶向抗疟疾药物的递送
5. Identification and characterization of aryl sulfonamides, a novel class of antitumor agents. [D] . Stachelek, Gregory Conrad. 2016

机译：芳基磺酰胺类（一类新型抗肿瘤药）的鉴定和表征。
6. Highly Active Anti-Pneumocystis carinii Compounds in a Library of Novel Piperazine-Linked Bisbenzamidines and Related Compounds [O] . Melanie T. Cushion, Peter D. Walzer, Margaret S. Collins, 2004

机译：新型哌嗪键联的双苯甲s和相关化合物库中的高活性抗肺孢子虫化合物
7. Highly Active Anti-Pneumocystis carinii Compounds in a Library of Novel Piperazine-Linked Bisbenzamidines and Related Compounds [O] . Cushion, Melanie T., Walzer, Peter D., Collins, Margaret S., 2004

机译：新型哌嗪键联的双苯甲s和相关化合物库中的高活性抗肺孢子虫化合物
8. Human Paraoxonase Double Mutants Hydrolyze V and G Class Organophosphorus Nerve Agents. [R] . Kirby, S. D., Norris, J. R., Smith, J. R., 2013

机译：人对氧磷酶双突变体水解V和G类有机磷神经毒剂。

Piperazine-linked bisbenzamidines: a novel class of antileishmanial agents.

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