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首页> 外文期刊>European Journal of Medicinal Chemistry: Chimie Therapeutique >In vitro and in vivo investigations on the antiviral activity of a series of mixed-valence rare earth borotungstate heteropoly blues.
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In vitro and in vivo investigations on the antiviral activity of a series of mixed-valence rare earth borotungstate heteropoly blues.

机译：一系列混合价稀土硼钨酸盐杂多蓝的抗病毒活性的体外和体内研究。

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A series of mixed-valence rare earth borotungsto-heteropoly blues, K15H2[Ln(BW9W2O39)2].28H2O (Ln2, Ln=La, Ce, Pr, Nd, Sm, Eu, Gd), have been prepared and characterized by IR, UV, XPS, ESR and electrochemistry. The cytotoxicity and antiviral activity of these rare earth borotungstate heteropoly blues were investigated against influenza A(FluVA) strain (A/H1N1/Jingfang/1/91 and A/H3N2/Jingfang/30/95) and influenza virus B(FluVB) (B/Hufang/1/87) in MDCK cells. The results show that K15H2[Pr(BW9W2O39)2].28H2O (Pr2) exhibits the highest antiviral activity against FluVA with EC50 of less than 4.0 microg/ml (A/H1N1/Jingfang/1/91) and 6.0 microg/ml (A/H3N2/Jingfang/30/95), respectively, and has the lowest toxicity with CC50 of more than 480 microg/ml against MDCK cells. Additionally, both K15H2[Pr(BW9W2O39)2].28H2O (Pr2) and K15H2[Eu(BW9W2O39)2].28H2O (Eu2) showed excellent antiviral activities against FluVB by inhibiting FluVB replication at an EC50 of less than 8.0 microg/ml. Furthermore, investigation on in vivo antiviral activity of Pr2 against FluVA(FM1) in mice by giving the dosage either orally (p.o.) or intraperitoneally (i.p.), indicates that Pr2 exhibits higher inhibitory activity than that of positive control, virazole, and that it's more effective when administered by i.p.
机译：制备了一系列混合价稀土杂原子勃艮第蓝K15H2 [Ln（BW9W2O39）2] .28H2O（Ln2，Ln = La，Ce，Pr，Nd，Sm，Eu，Gd）并进行了表征，UV，XPS，ESR和电化学。研究了这些稀土硼钨酸盐杂多蓝对A型流感病毒（FluVA）（A / H1N1 / Jingfang / 1/91和A / H3N2 / Jingfang / 30/95）和B型流感病毒（FluVB）的细胞毒性和抗病毒活性（ B / Hufang / 1/87）。结果表明，K15H2 [Pr（BW9W2O39）2] .28H2O（Pr2）对FluVA表现出最高的抗病毒活性，其EC50分别小于4.0 microg / ml（A / H1N1 / Jingfang / 1/91）和6.0 microg / ml（ A / H3N2 / Jingfang / 30/95），对MDCK细胞的CC50毒性最低，超过480 microg / ml。此外，K15H2 [Pr（BW9W2O39）2] .28H2O（Pr2）和K15H2 [Eu（BW9W2O39）2] .28H2O（Eu2）均通过在低于8.0 microg / ml的EC50上抑制FluVB复制而显示出优异的抗FluVB抗病毒活性。 。此外，通过口服（po）或腹膜内（ip）剂量研究小鼠中Pr2对FluVA（FM1）的体内抗病毒活性，表明Pr2的抑制活性高于阳性对照virazole。 ip给药更有效

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