Synthesis, characterization, DNA cleavage and in vitro antimicrobial studies of La(III), Th(IV) and VO(IV) complexes with Schiff bases of coumarin derivatives.

Kulkarni A; Patil SA; Badami PS

首页> 外文期刊>European Journal of Medicinal Chemistry: Chimie Therapeutique >Synthesis, characterization, DNA cleavage and in vitro antimicrobial studies of La(III), Th(IV) and VO(IV) complexes with Schiff bases of coumarin derivatives.

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Synthesis, characterization, DNA cleavage and in vitro antimicrobial studies of La(III), Th(IV) and VO(IV) complexes with Schiff bases of coumarin derivatives.

机译：具有香豆素衍生物席夫碱的La（III），Th（IV）和VO（IV）配合物的合成，表征，DNA裂解和体外抗菌研究。

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A series of La(III), Th(IV) and VO(IV) complexes have been synthesized with Schiff bases derived from 8-formyl-7-hydroxy-4-methylcoumarin and o-phenylenediamine/ethylenediamine. The structure of the complexes has been proposed in the light of analytical, spectral (IR, UV-vis, ESR and FAB-mass), Magnetic and thermal studies. The complexes are soluble in DMF and DMSO. The measured molar conductance values indicate that, the complexes are non-electrolytes in nature. The redox behavior of the complexes was investigated by electrochemical method using cyclic voltammetry. The Schiff bases and their complexes have been screened for their antibacterial (Escherichia coli, Staphylococcus aureus, Pseudomonas aeruginosa and Salmonella typhi) and antifungal activities (Aspergillus niger, Aspergillus flavus and cladosporium) by Minimum Inhibitory Concentration method. The DNA cleavage activity of La(III) and VO(IV) metal complexes is studied by agarose gel electrophoresis method.

机译：已经用衍生自8-甲酰基-7-羟基-4-甲基香豆素和邻苯二胺/乙二胺的席夫碱合成了一系列La（III），Th（IV）和VO（IV）配合物。结合分析，光谱（红外，紫外可见，ESR和FAB质量），磁学和热学研究提出了络合物的结构。该络合物可溶于DMF和DMSO。测得的摩尔电导值表明，该络合物本质上是非电解质。使用循环伏安法通过电化学方法研究了配合物的氧化还原行为。已通过最小抑菌浓度法对席夫碱及其复合物的抗菌（大肠埃希氏菌，金黄色葡萄球菌，铜绿假单胞菌和鼠伤寒沙门氏菌）和抗真菌活性（黑曲霉，黄曲霉和cladosporium）进行了筛选。通过琼脂糖凝胶电泳方法研究了La（III）和VO（IV）金属配合物的DNA裂解活性。

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《European Journal of Medicinal Chemistry: Chimie Therapeutique》 |2009年第7期|共9页
作者
Kulkarni A; Patil SA; Badami PS;
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1. Synthesis, characterization, DNA cleavage and in vitro antimicrobial studies of La(III), Th(IV) and VO(IV) complexes with Schiff bases of coumarin derivatives. [J] . Kulkarni A, Patil SA, Badami PS European Journal of Medicinal Chemistry: Chimie Therapeutique . 2009,第7期

机译：具有香豆素衍生物席夫碱的La（III），Th（IV）和VO（IV）配合物的合成，表征，DNA裂解和体外抗菌研究。
2. Synthesis,characterization,electrical and biological studies of Cr(III),Mn(III),Fe(III), Ti(III),VO(IV),Th(IV),Zr(IV) and UO2(VI) polychelates with bis-bidentate Schiff base [J] . A S Aswar, A D Bansod, S R Aswale Indian Journal of Chemistry, Section A. Inorganic, Physical, Theoretical & Analytical . 2004,第9期

机译：Cr（III），Mn（III），Fe（III），Ti（III），VO（IV），Th（IV），Zr（IV）和UO2（VI）多螯合物的合成，表征，电学和生物学研究双齿席夫碱
3. Synthesis, characterization, DNA cleavage, and in-vitro antimicrobial studies of Co(II), Ni(II), and Cu(II) complexes with Schiff bases of coumarin derivatives [J] . SANGAMESH A. PATIL, VINOD H. NAIK, AJAYKUMAR D. KULKARNI Journal of Coordination Chemistry . 2011,第15a16期

机译：Co（II），Ni（II）和Cu（II）与香豆素衍生物的席夫碱配合物的合成，表征，DNA裂解和体外抗菌研究
4. New complexes of lanthanum La(III) and Cerium Ce(III) with bis-coumarins. Synthesis, characterization and cytotoxicity for human lymphoblastoid cells (MT-2) [C] . Kostova, I., Raleva, Workshop on Macro, Trace and Ultratrace Elements; 20040924-25; Jena(DE) . 2004

机译：镧La（III）和Ce Ce（III）与双香豆素的新配合物。人淋巴母细胞（MT-2）的合成，表征和细胞毒性
5. The structure and reactivity of a series of high-valent oxo complexes of Ru and Mn: Ru(III)-mediated catalytic oxygenation of triphenylphosphine, characterization of binuclear Mn(III,III) and Mn(III,IV) dimers, and mononuclear iron(III) and iron(IV). [D] . Fackler, Nathanael L. P. 1997

机译：Ru和Mn的一系列高价羰基配合物的结构和反应性：Ru（III）介导的三苯膦催化氧化，双核Mn（III，III）和Mn（III，IV）二聚体的表征以及单核铁（III）和铁（IV）。
6. Novel Organotin(IV)-Schiff Base Complexes: Synthesis Characterization Antimicrobial Activity and DNA Interaction Studies [O] . K. Shiva Prasad, L. Shiva Kumar, Melvin Prasad, 2010

机译：新型有机锡（IV）-席夫碱复合物：合成表征抗菌活性和DNA相互作用研究
7. DNA binding, BSA interaction and in-vitro antimicrobial studies of Cu(II), Co(III), Ni(II) and VO(IV) complexes with a new Schiff base [O] . Disha Sharma, Hosakere D. Revanasiddappa, Basavegowda Jayalakshmi 2020

机译：DNA结合，BSA相互作用和Cu（II），CO（III），Ni（II）和VO（IV）复合物与新的Schiff Base的综合性抗微生物研究

Synthesis, characterization, DNA cleavage and in vitro antimicrobial studies of La(III), Th(IV) and VO(IV) complexes with Schiff bases of coumarin derivatives.

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