首页> 外文期刊>European Journal of Medicinal Chemistry: Chimie Therapeutique >Synthesis, characterization and antibacterial activity of some triazole Mannich bases carrying diphenylsulfone moieties.
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Synthesis, characterization and antibacterial activity of some triazole Mannich bases carrying diphenylsulfone moieties.

机译:一些带有二苯砜部分的三唑曼尼希碱的合成,表征和抗菌活性。

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摘要

A series of Mannich bases of 4-substituted 5-[4-(4-X-phenylsulfonyl)phenyl]-2,4-dihydro-3H-1,2,4-triazole-3-thiones, X=H, Cl, Br, 3 and 5 were synthesized and characterized on the basis of IR, NMR and elemental analyses. The potential antibacterial effects of the synthesized compounds were investigated using the Acinetobacter baumanii ATCC 19606; Citrobacter freundii ATCC 8090; Pseudomonas aeruginosa ATCC 9027; Enterococcus faecalis ATCC 19433; Staphylococcus aureus ATCC 12600; Staphylococcus epidermidis ATCC 14990; Bacillus subtilis ATCC 6633 strains. Some of them exhibited promising activities against A. baumanii and B. subtilis.
机译:4-取代的5- [4-(4-X-苯基磺酰基)苯基] -2,4-二氢-3H-1,2,4-三唑-3-硫酮的一系列曼尼希碱,X = H,Cl,根据IR,NMR和元素分析合成了Br,3和5并对其进行了表征。使用鲍曼不动杆菌ATCC 19606研究了合成化合物的潜在抗菌作用。弗氏柠檬酸杆菌ATCC 8090;铜绿假单胞菌ATCC 9027;粪肠球菌ATCC 19433;金黄色葡萄球菌ATCC 12600;表皮葡萄球菌ATCC 14990;枯草芽孢杆菌ATCC 6633菌株。他们中的一些表现出对鲍曼不动杆菌和枯草芽孢杆菌的有希望的活性。

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