Synthesis and antinociceptive activities of some pyrazoline derivatives.

Turan Zitouni Gülhan; Ozdemir Ahmet; Can Ozgür v; Chevallet Pierre

首页> 外文期刊>European Journal of Medicinal Chemistry: Chimie Therapeutique >Synthesis and antinociceptive activities of some pyrazoline derivatives.

【24h】

Synthesis and antinociceptive activities of some pyrazoline derivatives.

机译：某些吡唑啉衍生物的合成和抗伤害作用。

获取原文

获取原文并翻译 | 示例

掌桥外文数据库（机构版） >>

开具论文收录证明 >>

文献代查 >>

页面导航

摘要
著录项
相似文献
相关主题

摘要

In the present study, some pyrazoline derivatives were synthesized to investigate their potential antinociceptive activities. 1-[(Benzoxazole/benzimidazole-2-yl)thioacetyl]pyrazoline derivatives were obtained by reacting 3,5-diaryl-1-(2-chloroacetyl)pyrazolines with 2-marcaptobenzoxazole/benzimidazole. The chemical structures of the compounds were elucidated by IR, (1)H NMR and FAB(+)-MS spectral data and Elemental Analyses. All of the compounds (100 mg/kg) exhibited significant antinociceptive activities in both hot plate and acetic acid-induced writhing tests. Naloxone (5 mg/kg) pre-treatment reversed the antinociceptive activities suggesting the involvement of opioid system in the analgesic actions. None of the compounds impaired motor coordination of animals when assessed in the Rota-Rod model. These results support the previous papers reporting the opioid sensitive antinociceptive activities of various benzoxazole/benzimidazole-pyrazoline derivative compounds.

机译：在本研究中，合成了一些吡唑啉衍生物以研究其潜在的抗伤害感受活性。通过使3，5-二芳基-1-（2-氯乙酰基）吡唑啉与2-巯基苯并恶唑/苯并咪唑反应获得1-[（苯并恶唑/苯并咪唑-2-基）硫代乙酰基]吡唑啉衍生物。化合物的化学结构通过IR，（1）H NMR和FAB（+）-MS光谱数据以及元素分析得到阐明。所有化合物（100 mg / kg）在热板和乙酸诱导的扭体试验中均显示出显着的抗伤害感受活性。纳洛酮（5 mg / kg）预处理逆转了抗伤害感受活性，表明阿片样物质系统参与了镇痛作用。在Rota-Rod模型中评估时，没有一种化合物会损害动物的运动协调能力。这些结果支持了以前的论文，该论文报道了各种苯并恶唑/苯并咪唑-吡唑啉衍生物化合物对阿片类药物的镇痛活性。

著录项

来源
《European Journal of Medicinal Chemistry: Chimie Therapeutique》 |2009年第6期|共5页
作者
Turan Zitouni Gülhan; Ozdemir Ahmet; Can Ozgür v; Chevallet Pierre;
展开▼
作者单位

展开▼
收录信息
原文格式 PDF
正文语种 eng
中图分类药学;
关键词

相似文献

外文文献
中文文献
专利

1. Synthesis and antinociceptive activities of some pyrazoline derivatives. [J] . Turan Zitouni Gülhan, Ozdemir Ahmet, Can Ozgür v, European Journal of Medicinal Chemistry: Chimie Therapeutique . 2009,第6期

机译：某些吡唑啉衍生物的合成和抗伤害作用。
2. Antinociceptive activity of new imidazolidine carbonyl derivatives. Part 4. Synthesis and pharmacological activity of 8-aryl-3,4-dioxo-2H,8H-6,7-dihydroimidazo(2,1-c) (1,2,4)triazines. [J] . Sztanke K, Fidecka S, Kedzierska E, European Journal of Medicinal Chemistry: Chimie Therapeutique . 2005,第2期

机译：新的咪唑烷羰基衍生物的抗伤害感受活性。第4部分。8-芳基-3,4-二氧代-2H，8H-6,7-二氢咪唑并（2,1-c）（1,2,4）三嗪的合成和药理活性。
3. Synthesis, Anti-bacterial, Anti-fungal and Anti-inflammatory Activities of Some Novel 3, 5-Diaryl-1-Aryl Pyrazoline Derivatives. [J] . M. D. Bhanushali, S. M. Hipparagi Asian journal of research in chemistry . 2013,第7期

机译：某些新型3，5-二芳基-1-芳基吡唑啉衍生物的合成，抗菌，抗真菌和抗炎活性。
4. Synthesis /V-Phenyl Pyrazoline from Dibenzalacetone and Heme Polymeration Inhibitory Activity (HPIA) Assay [C] . Linda Ekawati, Bambang Purwono, Muhammad Idham Darussalam Mardjan International Conference on Science and Technology . 2020

机译：来自二苯甲酸盐和血红素聚合物抑制活性（HPIA）测定的合成/ V-苯基吡唑啉
5. Isolation, identification and synthesis of hydromorphone metabolites: Analysis and antinociceptive activities in comparison to morphine. [D] . Zheng, Ming. 1997

机译：氢吗啡酮代谢物的分离，鉴定和合成：与吗啡相比，分析和镇痛活性。
6. Synthesis and antifungal activity of novel pyrazolines and isoxazolines derived from cuminaldehyde [O] . Tao Zhang, Mengya Dong, Jianjiang Zhao, 2019

机译：异丙苯二甲醛衍生的新型吡唑啉和异恶唑啉的合成及抗真菌活性
7. Novel phenoxyalkylamine derivatives. IV. Synthesis, Ca2+-antagonistic activity and quantitative structure-activity analysis of .ALPHA.-isopropyl-.ALPHA.-(3-(3-(3-methoxyphenoxy)propylamino)propyl)-.ALPHA.-phenylacetonitrile derivatives. [O] . KAZUYA MITANI, SHUNICHIRO SAKURAI, TOSHIHIRO SUZUKI, 1988

机译：新型苯氧烷基胺衍生物。 IV。合成，Ca2 + - 致白性活性和定量结构 - 活性分析。 - 异丙基 - α-α-（3-（3-（3-（3-（3-甲氧基氧基）丙基氨基）丙基） - 。α-苯基乙腈衍生物。

Synthesis and antinociceptive activities of some pyrazoline derivatives.

摘要

著录项

相似文献

相关主题

期刊订阅