A novel and efficient one step synthesis of 2-amino-5-cyano-6-hydroxy-4-aryl pyrimidines and their anti-bacterial activity.

Salunkhe S M; Patil D R; Anbhule P V

首页> 外文期刊>European Journal of Medicinal Chemistry: Chimie Therapeutique >A novel and efficient one step synthesis of 2-amino-5-cyano-6-hydroxy-4-aryl pyrimidines and their anti-bacterial activity.

【24h】

A novel and efficient one step synthesis of 2-amino-5-cyano-6-hydroxy-4-aryl pyrimidines and their anti-bacterial activity.

机译：2-氨基-5-氰基-6-羟基-4-芳基嘧啶的新型高效一步合成及其抗菌活性。

获取原文

获取原文并翻译 | 示例

掌桥外文数据库（机构版） >>

开具论文收录证明 >>

文献代查 >>

页面导航

摘要
著录项
相似文献
相关主题

摘要

The first simple and efficient approach towards one step synthesis of 2-amino-5-cyano-6-hydroxy-4-aryl pyrimidines has been developed by three component condensation of aromatic aldehydes, ethyl cyanoacetate and guanidine hydrochloride in alkaline ethanol. The synthesized compounds evaluated for their anti-bacterial activity against gram-positive and gram-negative bacteria. The some of the compounds showed excellent zone of inhibition against tested bacteria.

机译：通过在碱性乙醇中芳族醛，氰基乙酸乙酯和盐酸胍的三组分缩合，已经开发出第一种简单有效的一步合成2-氨基-5-氰基-6-羟基-4-芳基嘧啶的方法。合成的化合物评估了它们对革兰氏阳性和革兰氏阴性细菌的抗菌活性。一些化合物对被测细菌表现出优异的抑制作用。

著录项

来源
《European Journal of Medicinal Chemistry: Chimie Therapeutique》 |2009年第6期|共4页
作者
Salunkhe S M; Patil D R; Anbhule P V;
展开▼
作者单位

展开▼
收录信息
原文格式 PDF
正文语种 eng
中图分类药学;
关键词

相似文献

外文文献
中文文献
专利

1. A novel and efficient one step synthesis of 2-amino-5-cyano-6-hydroxy-4-aryl pyrimidines and their anti-bacterial activity. [J] . Salunkhe S M, Patil D R, Anbhule P V European Journal of Medicinal Chemistry: Chimie Therapeutique . 2009,第6期

机译：2-氨基-5-氰基-6-羟基-4-芳基嘧啶的新型高效一步合成及其抗菌活性。
2. An efficient synthesis, characterization and anti-bacterial activity of pyrimidine bearing 1,3,4-thiadiazole derivatives [J] . Andrews B., Ahmed Mansur Indian Journal of Chemistry, Section B. Organic Including Medicinal . 2015,第3期

机译：带有1,3,4-噻二唑衍生物的嘧啶的有效合成，表征和抗菌活性
3. Heterocyclic synthesis via enaminonttriles:an efficient.one step synthesis of some novel azolo[1,5-#alpha#]pyrimidine,pyrimido[1,2-#alpha#]-benzimidazole,pyrido[1,2-#alpha#]benzimidazole pyrimidine and pyrazole derivatives [J] . Eljazi I.Al-Afaleq Synthetic Communications . 2000,第11期

机译：通过烯腈杂环合成：一种新颖的氮杂[1,5-＃alpha＃]嘧啶，嘧啶[1,2-＃alpha＃]-苯并咪唑，吡啶并[1,2-＃alpha＃]苯并咪唑的高效一步合成嘧啶和吡唑衍生物
4. Efficient Synthesis of Pyrimidine-nucleoside Monophosphates from W-Phosphonates [C] . Jian Sun, Shanshan Gong, Qi Sun International Conference on Energy Materials and Material Application . 2014

机译：从W-膦酸盐的高效合成嘧啶-核苷的单磷酸酯
5. Control of Pyrimidine Biosynthesis in Pseudomonas aurantiaca by Pyrimidines [D] . Domakonda, Anvesh. 2018

机译：用嘧啶对吡啶基菌根的嘧啶生物合成的控制
6. The Pyrimidine Nucleotide Reductase Step in Riboflavin and F420 Biosynthesis in Archaea Proceeds by the Eukaryotic Route to Riboflavin [O] . Marion Graupner, Huimin Xu, Robert H. White 2002

机译：核黄素中的嘧啶核苷酸还原酶步骤和古细菌中的F420生物合成通过核黄素的真核途径进行。
7. A facile and efficient one-pot three-step protocol for synthesis of 6-aryl-7-oxo-5-aryoxy/alkoxy-1-(p-tolyl)-6,7-dihydro-1H-pyrazolo[4,3-d]pyrimidine-3-carbonitrile [O] . Ming-Hu Wu, Ji-Huan Hu, Hai-Bing Guo, 2012

机译：用于合成6-芳基-7-氧代-5-芳氧基/烷氧基-1-（对甲苯基）-6,7-二氢-1H-吡唑并[4,3-]的简便有效的一锅法三步方案d]嘧啶-3-腈

A novel and efficient one step synthesis of 2-amino-5-cyano-6-hydroxy-4-aryl pyrimidines and their anti-bacterial activity.

摘要

著录项

相似文献

相关主题

期刊订阅