Synthesis and innate immunosuppressive effect of 1,2-cyclopentanediol derivatives.

Kikuchi H; Okazaki K; Sekiya M; Uryu Y; Ueda K; Katou Y; Kurata S; Oshima Y

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Synthesis and innate immunosuppressive effect of 1,2-cyclopentanediol derivatives.

机译：1,2-环戊二醇衍生物的合成及其先天免疫抑制作用。

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Innate immunity is the front line of self-defense against infectious microorganisms. In mammals, innate immunity interacts with adaptive immunity and plays a key role in regulating the immune response. Therefore, innate immunity is a good pharmaceutical target for the development of immune regulators. After searching for natural substances that regulate innate immunity using an ex vivo Drosophila culture system, we identified a cyclopentanediol-type compound 1 as an immunosuppressor. In this study, we synthesized and evaluated 1 and its derivatives. Several methylamide- or phenylamide-containing derivatives showed effects that were 20-25 times more potent than those of 1.

机译：天生的免疫力是针对传染性微生物的自我防御的最前沿。在哺乳动物中，先天免疫与适应性免疫相互作用，并在调节免疫反应中起关键作用。因此，先天免疫是免疫调节剂开发的良好药物靶标。在使用离体果蝇培养系统搜索调节先天性免疫力的天然物质后，我们确定了环戊二醇型化合物1作为免疫抑制剂。在这项研究中，我们合成并评估了1及其衍生物。几种含甲酰胺或苯甲酰胺的衍生物的功效比1的功效高20-25倍。

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《European Journal of Medicinal Chemistry: Chimie Therapeutique》 |2011年第4期|共11页
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Kikuchi H; Okazaki K; Sekiya M; Uryu Y; Ueda K; Katou Y; Kurata S; Oshima Y;
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中图分类药学;
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1. Synthesis and innate immunosuppressive effect of 1,2-cyclopentanediol derivatives. [J] . Kikuchi H, Okazaki K, Sekiya M, European Journal of Medicinal Chemistry: Chimie Therapeutique . 2011,第4期

机译：1,2-环戊二醇衍生物的合成及其先天免疫抑制作用。
2. Synthesis of a new highly-fluorinated cis-1,2-cyclopentanediol and its application for fluorinated oligoesters [J] . Agou Tomohiro, Ohata Ryo, Mizuhata Yoshiyuki, Journal of Fluorine Chemistry . 2018,第期

机译：新型高氟化性CIS-1,2-环戊烷二醇的合成及其氟化寡酯酯
3. Stereoselective synthesis of 1-methyl-1,2-and 1,3-cyclopentanediols via γ-lactones [J] . Niidu A., Paju A., Müürisepp A.-M., Chemistry of heterocyclic compounds . 2013,第12期

机译：通过γ-内酯立体选择性合成1-甲基-1,2-和1,3-环戊二醇
4. Synthesis and Characterization of Transition Metal Complexes of 1,2-Bis(3,5-dimethylpyrazol-1 -yl)-1,2-ethanediol [C] . Galyna A. Anosova, Vladislava V. Matveevskaya, Nurgul A. Pirmanova International Conference for Young Scientists "High Technology: Research and Applications" . 2016

机译：1,2-双（3,5-二甲基吡唑-1-基）-1,2-乙二醇的过渡金属配合物的合成与表征
5. Synthesis of (1R,2R)-N1,N2-Dibenzylcyclohexane-1,2-diamine as an Auxiliary for a Stereoselective 1,4 Conjugate Addition Reaction; Construction of Polymer Bound (1R,2R)- 1,2-Cyclohexanediamine to evaluate the Solid-Phase Counterpart, and Methodology Development for Synthesis of Functionalized Oligothiophenes. [D] . Poorjahanshah, Homer. 2016

机译：（1R，2R）-N1，N2-二苄基环己烷-1，2-二胺作为立体选择性1，4共轭加成反应的助剂的合成；聚合物结合的（1R，2R）-1,2-环己二胺的构建以评价固相配对物，以及功能化寡聚噻吩的合成方法开发。
6. Diastereoselective Synthesis of Cyclopentanediols by InCl3/Al Mediated Intramolecular Pinacol Coupling Reaction in Aqueous Media [O] . Yunhua Chen, Jieping Wan, Chunyan Wang, 2008

机译：InCl3 / Al介导的分子内频哪醇偶联反应在水性介质中的非对映选择性合成环戊烷二醇
7. Retraction: Beltaïef et al. An Expeditious Synthesis of [1,2]Isoxazolidin-5-ones and [1,2]Oxazin-6-ones from Functional Allyl Bromide Derivatives. Molecules 2010, 15, 4094-4101 [O] . Martyn Rittman 2014

机译：撤回：Beltaïef等。从功能性烯丙基溴衍生物中快速合成[1,2]异恶唑烷-5-酮和[1,2]恶嗪-6-酮。 molecules 2010,15,4094-4101
8. Organolithium Routes to 1,2-Disubstituted Ethylene Derivatives. An Attempted Synthesis of 1,2-Dilithioethylene. [R] . Seyferth, D., Vick, S. C. 1977

机译：有机锂路由到1,2-二取代乙烯衍生物。试图合成1,2-二硫代乙烯。

Synthesis and innate immunosuppressive effect of 1,2-cyclopentanediol derivatives.

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