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How do I begin? Sensing extracellular stress to maintain yeast cell wall integrity

机译:我该如何开始?感知细胞外应激以维持酵母细胞壁完整性

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摘要

The cell wall integrity (CWI) signalling pathway is necessary to remodel the yeast cell wall during normal morphogenesis and in response to cell surface stress. In the Baker's yeast Saccharomyces cerevisiae, a set of five membrane-spanning sensors, namely Wsc1, Wsc2, Wsc3, Mid2 and Mtl1, detect perturbations in the cell wall and/or the plasma membrane and activate a downstream signal transduction pathway with a central MAP kinase module. As a consequence, the expression of genes whose products are involved in cell wall structure and remodelling is induced. This review summarises our recent results on sensor structure and function, as well as the advances made regarding sensor mechanics
机译:细胞壁完整性(CWI)信号通路对于在正常形态发生过程中以及响应细胞表面应激时重塑酵母细胞壁是必需的。在贝克酵母啤酒酵母中,一组五个跨膜传感器,即Wsc1,Wsc2,Wsc3,Mid2和Mtl1,可检测细胞壁和/或质膜中的扰动并通过中央MAP激活下游信号转导途径激酶模块。结果,诱导了其产物参与细胞壁结构和重塑的基因的表达。这篇综述总结了我们关于传感器结构和功能的最新研究成果,以及有关传感器力学的最新进展

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