...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>European Journal of Cell Biology: Journal of Deutsche Gesellschaft fur Elektronenmikroskopie: Journal of Deutsche Gesellschaft fur Zellbiologie >Regulation of human enteric alpha-defensins by NOD2 in the Paneth cell lineage
【24h】

Regulation of human enteric alpha-defensins by NOD2 in the Paneth cell lineage

机译：Paneth细胞谱系中NOD2对人类肠道α-防御素的调节

获取原文
获取原文并翻译 | 示例
   

获取外文期刊封面封底 >>

       
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Human enteric alpha-defensins (HD5 and HD6), major antimicrobial peptides produced by Paneth cells in the intestine, play important roles in intestinal innate immunity. Since their expression is decreased in Crohn's disease (CD), with decreased expression being more pronounced in the presence of NOD2 mutations, it would be extremely interesting to investigate the mechanism by which NOD2 may regulate expression of human enteric a-defensins. Here we show that although NOD2 by itself can slightly up-regulate expression of enteric a-defensins mainly through activation of the NF-kappa B pathway, it can strongly down-regulates their expression during differentiation of the Paneth cell lineage mainly by inhibiting activation of the MAPK pathway. Since NOD2 is over-expressed in CD and mutant NOD2 cannot result in NF-kappa B activity, our finding can provide an explanation of the previous observation showing decreased expression of human enteric a-defensin in CD and even more so in the presence of NOD2 mutations. In addition, this finding provides a new view on the function of NOD2 in regulating intestinal innate immunity. (C) 2014 Elsevier GmbH. All rights reserved.
机译：人肠道α-防御素（HD5和HD6）是肠道Paneth细胞产生的主要抗菌肽，在肠道先天免疫中起着重要作用。由于在克罗恩氏病（CD）中它们的表达下降，而在NOD2突变的存在下表达下降更为明显，因此研究NOD2调节人类肠道α-防御素表达的机制将非常有趣。在这里我们显示，虽然NOD2本身可以主要通过激活NF-κB途径稍微上调肠a-防御素的表达，但它可以通过抑制Paneth细胞谱系的激活而强烈下调其表达。 MAPK途径。由于NOD2在CD中过表达并且突变型NOD2不能导致NF-κB活性，因此我们的发现可以为先前的观察结果提供解释，该结果显示了人类肠道a-防御素在CD中的表达降低，甚至在存在NOD2时更是如此。突变。此外，这一发现为NOD2在调节肠道先天免疫中的功能提供了新的视角。 （C）2014 Elsevier GmbH。版权所有。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号