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Hypersensitivity reactions to nonsteroidal anti-inflammatory drugs

机译:对非甾体类抗炎药的超敏反应

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摘要

Nonsteroidal anti-inflammatory drugs (NSAIDs) are the drugs most commonly involved in hypersensitivity drug reactions. Such reactions can be due to the release of inflammatory mediators in the absence of specific immunologic recognition, or immunoglobulin E (IgE)- or T-cell-selective responses. The former include upper and lower airway symptoms in patients with chronic underlying respiratory disease, the exacerbation of chronic spontaneous urticaria, and the induction of cutaneous symptoms. The latter include selective responses to a single NSAID with good tolerance to strong cyclooxygenase-1 inhibitors, with a putative IgE or T-cell mechanism proposed. These reactions can be acute or delayed.
机译:非甾体抗炎药(NSAIDs)是超敏反应中最常见的药物。此类反应可能是由于在没有特异性免疫学识别或免疫球蛋白E(IgE)或T细胞选择性反应的情况下炎性介质的释放所致。前者包括患有慢性基础呼吸道疾病的患者的上呼吸道症状和下呼吸道症状,慢性自发性荨麻疹的加重以及皮肤症状的诱发。后者包括对单一NSAID的选择性反应,对强环加氧酶-1抑制剂具有良好的耐受性,并提出了可能的IgE或T细胞机制。这些反应可能是急性的也可能是延迟的。

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