Human cord blood γδ T cells expressing public Vγ2 chains dominate the response to bisphosphonate plus interleukin-15

CairoC.; SagniaB.; CappelliG.; ColizziV.; LekeR.G.F.; LekeR.J.; PauzaC.D.

首页> 外文期刊>Immunology: An Official Journal of the British Society for Immunology >Human cord blood γδ T cells expressing public Vγ2 chains dominate the response to bisphosphonate plus interleukin-15

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Human cord blood γδ T cells expressing public Vγ2 chains dominate the response to bisphosphonate plus interleukin-15

机译：表达公共Vγ2链的人脐血γδT细胞主导了对双膦酸酯加白介素15的反应

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Summary: Compared with adults, the circulating Vγ2Vδ2 T-cell population in cord blood is present at low levels and does not show the strong bias for Vγ2-Jγ1.2 rearrangements. These features may be a result of limited exposure to stimulatory phosphoantigens, lack of T-cell-derived interleukin-2 (IL-2) or both. In cord blood mononuclear cell cultures, a single round of stimulation, using aminobisphosphonates to elevate phosphoantigen levels, resulted in expansion of adult-like Vγ2 chains and accumulation of memory cells with cytotoxic potential. Selection was similar using IL-2 or myeloid-derived IL-15. The Vγ2Vδ2 T cells present in neonates are capable of generating potent immune responses even when relying on IL-15.

机译：摘要：与成人相比，脐带血中循环的Vγ2Vδ2T细胞数量低，并且对Vγ2-Jγ1.2重排没有强烈的偏见。这些特征可能是由于刺激性磷抗原暴露有限，缺乏T细胞衍生的白介素2（IL-2）或两者兼有的结果。在脐带血单核细胞培养物中，使用氨基双膦酸盐提高磷酸抗原水平的单轮刺激导致成年状Vγ2链的扩增和具有细胞毒性潜力的记忆细胞的积累。使用IL-2或髓样来源的IL-15的选择相似。即使依靠IL-15，新生儿中存在的Vγ2Vδ2T细胞也能够产生有效的免疫反应。

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《Immunology: An Official Journal of the British Society for Immunology》 |2013年第4期|共15页
作者
CairoC.; SagniaB.; CappelliG.; ColizziV.; LekeR.G.F.; LekeR.J.; PauzaC.D.;
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原文格式 PDF
正文语种 eng
中图分类医学免疫学;
关键词
Gammadelta; interleukin-15; Neonatal; repertoire;

机译：伽玛三角洲;白介素15;新生儿;曲目;

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1. Human cord blood γδ T cells expressing public Vγ2 chains dominate the response to bisphosphonate plus interleukin-15 [J] . CairoC., SagniaB., CappelliG., Immunology: An Official Journal of the British Society for Immunology . 2013,第4期

机译：表达公共Vγ2链的人脐血γδT细胞主导了对双膦酸酯加白介素15的反应
2. Gene expression profiling of CD3γ, δ, ?, and ζ chains in CD4sup+/sup and CD8sup+/sup T cells from human umbilical cord blood [J] . Shaohua Chen, Lijian Yang, Xiaoye Lu, Hematology . 2010,第4期

机译：人脐带血CD4 + 和CD8 + T细胞中CD3γ，δ，γ和ζ链的基因表达谱
3. Cytotoxicity of Human Cord Blood Natural Killer Cells is Enhanced by Recombinant Interleukin-15 [J] . Shiva Saghafi, Ali Akbar Pourfathollah, Maryam Kheirandish, Iranian Journal Of Allergy, Asthma and Immunology . 2010,第2期

机译：重组白介素15增强人脐带血天然杀伤细胞的细胞毒性
4. First Trimester Human Umbilical Cord Perivascular Cells Accelerate and Enhance Network Formation of Human Blood Outgrowth Endothelial Cells in 3D Matrigel Environments [C] . Yarden S. Gratch, Peter Szaraz, Clifford L. Librach Society for Biomaterials annual meeting and exposition . 2017

机译：头三个月的人脐带血管周围细胞在3D Matrigel环境中加速并增强了人类血液外生内皮细胞的网络形成
5. Diversity of Cytokine Expression Patterns in the Th1-Dominated Human Anti-Influenza CD4 T Cell Response Is Due To Both Variable Expression of Cytokines by Committed Th1 Cells, and a Minor Population of Uncommitted IL-2+IFNγ- Thpp Cells [D] . Deng, Nan 2014

机译：Th1为主的人类抗流感CD4 T细胞反应中细胞因子表达模式的多样性是由于既定的Th1细胞可变表达细胞因子，以及少数未定型的IL-2 +IFNγ-Thpp细胞引起的。
6. Human cord blood γδ T cells expressing public Vγ2 chains dominate the response to bisphosphonate plus interleukin-15 [O] . Cristiana Cairo, Bertrand Sagnia, Giulia Cappelli, 2013

机译：表达公共Vγ2链的人脐血γδT细胞主导了对双膦酸酯加白介素15的反应
7. Human Renal Cancer Cells Express a Novel Membrane-Bound Interleukin-15 that Induces, in Response to the Soluble Interleukin-15 Receptor α Chain, Epithelial-to-Mesenchymal Transition [O] . Khawam, Krystel, Giron-Michel, Julien, Ludwig, Andreas, 2009

机译：人肾癌细胞表达一种新型膜结合白介素-15，其响应可溶性白介素15受体α链而诱导上皮向间质转化

Human cord blood γδ T cells expressing public Vγ2 chains dominate the response to bisphosphonate plus interleukin-15

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