...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Immunology: An Official Journal of the British Society for Immunology >Bridging effect of recombinant human mannose-binding lectin in macrophage phagocytosis of Escherichia coli.
【24h】

Bridging effect of recombinant human mannose-binding lectin in macrophage phagocytosis of Escherichia coli.

机译：重组人甘露糖结合凝集素在大肠杆菌巨噬细胞吞噬中的桥接作用。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Mannose-binding lectin (MBL) exists in the serum as a complex with MBL-associated serine protease (MASP). A recent paper described how MASP-free recombinant rat MBL stimulates the phagocytosis of Escherichia coli and Staphylococcus aureus by rat Kupffer cells through an increase in the level of a phagocytosis receptor. We have examined the effect of human MBL on the phagocytic action of human macrophages. Purified recombinant human MBL stimulated the phagocytosis of E. coli by THP-1 macrophages, leaving that of latex beads, apoptotic human cells, zymosan particles or S. aureus unchanged. This stimulatory effect was observed when either phagocytes or targets were preincubated with MBL. Furthermore, MBL bound to THP-1 macrophages as well as to E. coli, but not to S. aureus, through lipid A. These results indicated that human MBL in the absence of MASP stimulates macrophage phagocytosis of E. coli by bridging targets and phagocytes.
机译：甘露糖结合凝集素（MBL）与MBL相关丝氨酸蛋白酶（MASP）形成复合物。最近的一篇论文描述了无MASP的重组大鼠MBL如何通过吞噬作用受体水平的提高来刺激大鼠库普弗细胞对大肠杆菌和金黄色葡萄球菌的吞噬作用。我们已经检查了人类MBL对人类巨噬细胞吞噬作用的影响。纯化的重组人MBL通过THP-1巨噬细胞刺激大肠杆菌的吞噬作用，而乳胶珠，凋亡的人细胞，酵母聚糖颗粒或金黄色葡萄球菌的吞噬作用保持不变。当吞噬细胞或靶标与MBL预孵育时，观察到这种刺激作用。此外，MBL通过脂质A与THP-1巨噬细胞以及与大肠杆菌结合，但不与金黄色葡萄球菌结合。这些结果表明，在没有MASP的情况下，人MBL通过桥接靶标和靶点刺激大肠杆菌的巨噬细胞吞噬作用。吞噬细胞。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号