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首页> 外文期刊>Immunology: An Official Journal of the British Society for Immunology >Special regulatory T cell review: The resurgence of the concept of contrasuppression in immunoregulation.
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Special regulatory T cell review: The resurgence of the concept of contrasuppression in immunoregulation.

机译：特殊调节性T细胞综述：免疫调节中反抑制概念的复兴。

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摘要

The original concept of contrasuppression (CS) is evident in many immunoregulatory mechanisms. Inhibition of suppressor activity--CS--may be critical in microbial infection and autoimmunity. The major cellular interactions involved in suppression are the CD25+ FoxP3+ CD4+ T regulatory cells, programmed death-1 (PD-1) : PD-L1/L2 and cytotoxic T lymphocyte antigen-4 (CTLA-4) : CD80/86 pathways. These cellular functions are affected by dendritic cells (DC) and a complex array of cytokines of which interleukin (IL)-2, IL-10, IL-6 and transforming growth factor-beta (TGF-beta) are especially significant. Inhibition of regulatory cells, suppressor pathways or cytokines, is consistent with CS and can be attributed to IL-6, IL-2, PD-1 or PD-L-1 antibodies, blockade of CTLA-4 : CD80/86 pathway, inhibition of CD40-CD40L pathways, and TGF-beta, IL-10 antibodies. Contrasuppression may regulate innate immunity by Toll-like receptor expressed not only in non-cognate DC, monocytes, natural killer cells and gammadeltaT cells but also in adaptive T cells. Furthermore, cross-talk between innate and adaptive immunity may be facilitated by contrasuppressor activity. ''What's in a name? That which we call a rose by any other name would smell as sweet.'' From Romeo and Juliet (II, 47-8) W. Shakespeare.
机译：抑制（CS）的原始概念在许多免疫调节机制中均很明显。抑制物活性-CS-的抑制可能对微生物感染和自身免疫至关重要。参与抑制的主要细胞相互作用是CD25 + FoxP3 + CD4 + T调节细胞，程序性死亡1（PD-1）：PD-L1 / L2和细胞毒性T淋巴细胞抗原4（CTLA-4）：CD80 / 86途径。这些细胞功能受树突状细胞（DC）和细胞因子复杂阵列的影响，其中白介素（IL）-2，IL-10，IL-6和转化生长因子-β（TGF-β）尤为重要。抑制调节细胞，抑制途径或细胞因子与CS一致，可归因于IL-6，IL-2，PD-1或PD-L-1抗体，CTLA-4的阻断：CD80 / 86途径，抑制作用CD40-CD40L途径以及TGF-beta，IL-10抗体的鉴定。对调抑制不仅可以通过在非同源DC，单核细胞，自然杀伤细胞和γT细胞中表达的Toll样受体来调节先天免疫，而且可以在适应性T细胞中表达。此外，抑制物的活性可以促进先天性和适应性免疫之间的串扰。 ``名字叫什么？我们用别称的玫瑰来闻起来都香甜。”罗密欧与朱丽叶（II，47-8）W.莎士比亚。

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