...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Immunology: An Official Journal of the British Society for Immunology >T-cell recognition is shaped by epitope sequence conservation in the host proteome and microbiome
【24h】

T-cell recognition is shaped by epitope sequence conservation in the host proteome and microbiome

机译：T细胞识别是由宿主蛋白质组和微生物组中的表位序列保守性决定的

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Several mechanisms exist to avoid or suppress inflammatory T-cell immune responses that could prove harmful to the host due to targeting self-antigens or commensal microbes. We hypothesized that these mechanisms could become evident when comparing the immunogenicity of a peptide from a pathogen or allergen with the conservation of its sequence in the human proteome or the healthy human microbiome. Indeed, performing such comparisons on large sets of validated T-cell epitopes, we found that epitopes that are similar with self-antigens above a certain threshold showed lower immunogenicity, presumably as a result of negative selection of T cells capable of recognizing such peptides. Moreover, we also found a reduced level of immune recognition for epitopes conserved in the commensal microbiome, presumably as a result of peripheral tolerance. These findings indicate that the existence (and potentially the polarization) of T-cell responses to a given epitope is influenced and to some extent predictable based on its similarity to self-antigens and commensal antigens.
机译：存在几种避免或抑制炎症性T细胞免疫反应的机制，这些炎症性反应可能由于靶向自身抗原或共生微生物而对宿主有害。我们假设当将来自病原体或过敏原的肽的免疫原性与其在人类蛋白质组或健康人类微生物组中的序列保守性进行比较时，这些机制可能变得显而易见。确实，在大量经过验证的T细胞抗原决定簇上进行此类比较，我们发现与自身抗原高于某个阈值的相似抗原决定簇显示出较低的免疫原性，这大概是由于对能够识别此类肽的T细胞进行了负选择所致。此外，我们还发现对共生微生物组中保守的抗原决定簇的免疫识别水平降低，这大概是由于外周耐受所致。这些发现表明，针对给定表位的T细胞应答的存在（以及可能的极化）会受到影响，并且由于其与自身抗原和共生抗原的相似性，在一定程度上是可以预测的。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号