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首页> 外文期刊>Immunology: An Official Journal of the British Society for Immunology >Association of quantitative interferon-gamma responses with the progression of naturally acquired Mycobacterium bovis infection in wild European badgers (Meles meles)
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Association of quantitative interferon-gamma responses with the progression of naturally acquired Mycobacterium bovis infection in wild European badgers (Meles meles)

机译：定量干扰素-γ反应与欧洲European（Meles meles）中自然获得的牛分枝杆菌感染进展的关系

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摘要

Bovine tuberculosis is one of the biggest challenges facing cattle farming in Great Britain. European badgers (Meles meles) are a reservoir host for the causal agent, Mycobacterium bovis. There have been significant recent advances in diagnostic testing for tuberculosis in humans, cattle and badgers, with the development of species-specific assays for interferon- (IFN-), an important cytokine in tuberculous infections. Using data collected from longitudinal studies of naturally infected wild badgers, we report that the magnitude of the IFN- response to M.bovis antigens at the disclosing test event was positively correlated with subsequent progression of disease to a seropositive or excreting state. In addition, we show that the magnitude of the IFN- response, despite fluctuation, declined with time after the disclosing event for all badgers, but remained significantly higher in those animals with evidence of disease progression. We discuss how our findings may be related to the immunopathogenesis of natural M.bovis infection in badgers.
机译：牛结核病是英国养牛业面临的最大挑战之一。欧洲badge（Meles meles）是病原体牛分枝杆菌的宿主。在人类，牛和badge的结核病诊断测试中，随着针对干扰素（IFN-）（一种在结核感染中的重要细胞因子）的物种特异性检测方法的发展，最近在诊断测试方面取得了重大进展。使用从自然感染的野生badge的纵向研究中收集的数据，我们报告了在披露的测试事件中，对牛分枝杆菌抗原的IFN-应答的强度与疾病随后发展为血清阳性或排泄状态呈正相关。另外，我们显示，尽管有fluctuation，IFN-应答的强度尽管有波动，但随时间下降，但在那些有疾病进展迹象的动物中，IFN-应答的强度仍显着较高。我们讨论了我们的发现如何可能与rs中天然牛分枝杆菌感染的免疫发病机制相关。

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