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首页> 外文期刊>Immunology: An Official Journal of the British Society for Immunology >T-cell receptor affinity in thymic development
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T-cell receptor affinity in thymic development

机译：胸腺发育中的T细胞受体亲和力

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Understanding the thymic processes that support the generation of functionally competent and self-tolerant lymphocytes requires dissection of the T-cell receptor (TCR) response to ligands of different affinities. In spatially segregated regions of the thymus, with unique expression of proteases and cytokines, TCR affinity guides a number of cell fate decisions. Yet affinity alone does not explain the selection paradox. Increasing evidence suggests that the 'altered peptide' model of the 1980s together with the affinity model might best explain how the thymus supports conventional and regulatory T-cell development. Development of new tools to study the strength of TCR signals perceived by T cells, novel regulatory T-cell transgenic mice, and tetramer enrichment strategies have provided an insight into the nature of TCR signals perceived during thymocyte development. These topics are discussed and support for the prevailing hypotheses is presented.
机译：了解支持功能性和自耐受性淋巴细胞生成的胸腺过程需要解剖T细胞受体（TCR）对不同亲和力配体的反应。在胸腺的空间分隔区域中，具有独特的蛋白酶和细胞因子表达，TCR亲和力指导许多细胞命运的决定。然而，仅亲和力并不能解释选择悖论。越来越多的证据表明，1980年代的“改变肽”模型与亲和力模型一起可能最好地解释了胸腺如何支持常规和调节性T细胞发育。开发新工具以研究T细胞感知的TCR信号强度，新型调节性T细胞转基因小鼠和四聚体富集策略，使人们对胸腺细胞发育期间感知到的TCR信号的性质有了深刻的了解。讨论了这些主题，并提出了对当前假设的支持。

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