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首页> 外文期刊>Immunology: An Official Journal of the British Society for Immunology >Dendritic cell-based immunity and vaccination against hepatitis C virus infection
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Dendritic cell-based immunity and vaccination against hepatitis C virus infection

机译：针对C型肝炎病毒感染的树突细胞免疫和疫苗接种

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Hepatitis C virus (HCV) has chronically infected an estimated 170million people worldwide. There are many impediments to the development of an effective vaccine for HCV infection. Dendritic cells (DC) remain the most important antigen-presenting cells for host immune responses, and are capable of either inducing productive immunity or maintaining the state of tolerance to self and non-self antigens. Researchers have recently explored the mechanisms by which DC function is regulated during HCV infection, leading to impaired antiviral T-cell responses and so to persistent viral infection. Recently, DC-based vaccines against HCV have been developed. This review summarizes the current understanding of DC function during HCV infection and explores the prospects of DC-based HCV vaccine. In particular, it describes the biology of DC, the phenotype of DC in HCV-infected patients, the effect of HCV on DC development and function, the studies on new DC-based vaccines against HCV infection, and strategies to improve the efficacy of DC-based vaccines.
机译：丙型肝炎病毒（HCV）慢性感染了全世界约1亿7千万人。开发用于HCV感染的有效疫苗有许多障碍。树突状细胞（DC）仍然是宿主免疫反应中最重要的抗原呈递细胞，能够诱导生产性免疫或维持对自身和非自身抗原的耐受状态。研究人员最近探索了在HCV感染过程中调节DC功能的机制，该机制可导致抗病毒T细胞反应受损，从而导致持续的病毒感染。最近，已经开发了针对HCV的基于DC的疫苗。这篇综述总结了目前对HCV感染期间DC功能的了解，并探讨了基于DC的HCV疫苗的前景。特别是，它描述了DC的生物学，HCV感染患者中DC的表型，HCV对DC发育和功能的影响，新型抗HCV感染的基于DC的疫苗的研究以及提高DC疗效的策略。疫苗。

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