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Invariant natural killer T cells and their ligands: focus on multiple sclerosis

机译:不变的自然杀伤性T细胞及其配体:专注于多发性硬化

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Invariant natural killer T (iNKT) cells are an innate population of T cells identified by the expression of an invariant T-cell receptor and reactivity to lipid-based antigens complexed with CD1d. They account for a small percentage of lymphocytes, but are extremely potent and play central roles in immunity to infection, in some cancers, and in autoimmunity. The list of relevant stimulatory lipids and glycolipid antigens now includes a range of endogenous self-antigens including the myelin-derived acetylated galactosylceramides. Recent progress in studies to identify the nature of lipid recognition for iNKT cells in autoimmune diseases like multiple sclerosis is likely to foster the development of therapeutic strategies aimed at harnessing iNKT cell activity.
机译:不变的自然杀伤性T细胞(iNKT)是由不变的T细胞受体的表达和对与CD1d复合的基于脂质的抗原的反应性所识别的T细胞的先天种群。它们仅占淋巴细胞的一小部分,但功能极为强大,并且在感染免疫,某些癌症和自身免疫中起着核心作用。相关的刺激性脂质和糖脂抗原列表现在包括一系列内源性自身抗原,包括髓磷脂衍生的乙酰化半乳糖基神经酰胺。在诸如多发性硬化症等自身免疫性疾病中鉴定iNKT细胞脂质识别性质的研究的最新进展可能会促进旨在利用iNKT细胞活性的治疗策略的发展。

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