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首页> 外文期刊>Immunology: An Official Journal of the British Society for Immunology >Type 2 diabetes mellitus is associated with altered CD8(+) T and natural killer cell function in pulmonary tuberculosis
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Type 2 diabetes mellitus is associated with altered CD8(+) T and natural killer cell function in pulmonary tuberculosis

机译：2型糖尿病与肺结核中CD8（+）T和自然杀伤细胞功能的改变有关

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Type 2 diabetes mellitus (DM) is associated with expanded frequencies of mycobacterial antigen-specific CD4(+) T helper type 1 (Th1) and Th17 cells in individuals with active pulmonary tuberculosis (TB). No data are available on the role of CD8(+) T and natural killer (NK) cells in TB with coincident DM. To identify the role of CD8(+) T and NK cells in pulmonary TB with diabetes, we examined mycobacteria-specific immune responses in the whole blood of individuals with TB and DM (TB-DM) and compared them with those without DM (TB-NDM). We found that TB-DM is characterized by elevated frequencies of mycobacterial antigen-stimulated CD8(+) T cells expressing type 1 [interferon- and interleukin-2 (IL-2)] and type 17 (IL-17F) cytokines. We also found that TB-DM is characterized by expanded frequencies of TB antigen-stimulated NK cells expressing type 1 (tumour necrosis factor-) and type 17 (IL-17A and IL-17F) cytokines. In contrast, CD8(+) T cells were associated with significantly diminished expression of the cytotoxic markers perforin, granzyme B and CD107a both at baseline and following antigen or anti-CD3 stimulation, while NK cells were associated with significantly decreased antigen-stimulated expression of CD107a only. This was not associated with alterations in CD8(+) T-cell or NK cell numbers or subset distribution. Therefore, our data suggest that pulmonary TB complicated with type 2 DM is associated with an altered repertoire of cytokine-producing and cytotoxic molecule-expressing CD8(+) T and NK cells, possibly contributing to increased pathology.
机译：2型糖尿病（DM）与患有活动性肺结核（TB）的个体中分枝杆菌抗原特异性CD4（+）T辅助1型（Th1）和Th17细胞的频率增加有关。没有资料显示CD8（+）T和天然杀手（NK）细胞在DM伴发的TB中的作用。为了确定CD8（+）T和NK细胞在糖尿病性肺结核中的作用，我们检查了患有TB和DM（TB-DM）的个体全血中分枝杆菌特异性免疫应答，并将其与没有DM（TB）的个体进行比较-NDM）。我们发现，TB-DM的特征是表达1型[干扰素和白介素2（IL-2）]和17型（IL-17F）细胞因子的分枝杆菌抗原刺激的CD8（+）T细胞的频率升高。我们还发现，TB-DM的特征是表达1型（肿瘤坏死因子）和17型（IL-17A和IL-17F）细胞因子的TB抗原刺激的NK细胞频率增加。相比之下，CD8（+）T细胞在基线和抗原或抗CD3刺激后均与细胞毒性标记穿孔素，颗粒酶B和CD107a的表达显着降低有关，而NK细胞与抗原刺激的T细胞的表达显着降低有关。仅CD107a。这与CD8（+）T细胞或NK细胞数目或亚群分布的改变无关。因此，我们的数据表明，肺结核并发2型DM与细胞因子产生和表达细胞毒分子的CD8（+）T和NK细胞的组成改变有关，可能导致病理增加。

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