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首页> 外文期刊>Immunology: An Official Journal of the British Society for Immunology >Regulation of TCR signalling by tyrosine phosphatases: From immune homeostasis to autoimmunity
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Regulation of TCR signalling by tyrosine phosphatases: From immune homeostasis to autoimmunity

机译：酪氨酸磷酸酶对TCR信号的调节：从免疫稳态到自身免疫

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More than half of the known protein tyrosine phosphatases (PTPs) in the human genome are expressed in T cells, and significant progress has been made in elucidating the biology of these enzymes in T-cell development and function. Here we provide a systematic review of the current understanding of the roles of PTPs in T-cell activation, providing insight into their mechanisms of action and regulation in T-cell receptor signalling, the phenotypes of their genetically modified mice, and their possible involvement in T-cell-mediated autoimmune disease. Our projection is that the interest in PTPs as mediators of T-cell homeostasis will continue to rise with further functional analysis of these proteins, and PTPs will be increasingly considered as targets of immunomodulatory therapies.
机译：人类基因组中超过一半的已知蛋白质酪氨酸磷酸酶（PTP）在T细胞中表达，在阐明这些酶在T细胞发育和功能中的生物学特性方面已取得了重大进展。在这里，我们提供了对PTP在T细胞活化中作用的当前理解的系统综述，从而深入了解了PTP在T细胞受体信号传导中的作用和调节机制，其转基因小鼠的表型以及它们可能参与的过程。 T细胞介导的自身免疫性疾病。我们的预测是，随着对这些蛋白质进行进一步的功能分析，对PTP作为T细胞稳态介导者的兴趣将继续上升，并且PTP将越来越被视为免疫调节疗法的靶标。

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