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首页> 外文期刊>Immunology: An Official Journal of the British Society for Immunology >Epistasis and immunity: The role of genetic interactions in autoimmune diseases
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Epistasis and immunity: The role of genetic interactions in autoimmune diseases

机译：上位性和免疫性：基因相互作用在自身免疫性疾病中的作用

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摘要

Autoimmune disorders are a complex and varied group of diseases that are caused by breakdown of self-tolerance. The aetiology of autoimmunity is multi-factorial, with both environmental triggers and genetically determined risk factors. In recent years, it has been increasingly recognized that genetic risk factors do not act in isolation, but rather the combination of individual additive effects, gene-gene interactions and gene-environment interactions determine overall risk of autoimmunity. The importance of gene-gene interactions, or epistasis, has been recently brought into focus, with research demonstrating that many autoimmune diseases, including rheumatic arthritis, autoimmune glomerulonephritis, systemic lupus erythematosus and multiple sclerosis, are influenced by epistatic interactions. This review sets out to examine the basic mechanisms of epistasis, how epistasis influences the immune system and the role of epistasis in two major autoimmune conditions, systemic lupus erythematosus and multiple sclerosis.
机译：自身免疫性疾病是由自我耐受力下降引起的一系列复杂多样的疾病。自身免疫的病因具有多种因素，既有环境触发因素，又有遗传确定的危险因素。近年来，人们越来越认识到遗传风险因素并不是孤立地起作用，而是个体累加效应，基因-基因相互作用和基因-环境相互作用的组合决定了自身免疫的总体风险。基因-基因相互作用或上位性的重要性近来已成为人们关注的焦点，研究表明，许多自身免疫性疾病，包括风湿性关节炎，自身免疫性肾小球肾炎，系统性红斑狼疮和多发性硬化症，都受到上位性相互作用的影响。这篇综述着手探讨上位性的基本机制，上位性如何影响免疫系统以及上位性在两种主要的自身免疫性疾病（系统性红斑狼疮和多发性硬化症）中的作用。

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