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首页> 外文期刊>Immunology: An Official Journal of the British Society for Immunology >Interleukin-4 promotes human CD8 T cell expression of CCR7.
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Interleukin-4 promotes human CD8 T cell expression of CCR7.

机译：白介素4促进CCR7的人类CD8 T细胞表达。

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摘要

Despite strong evidence supporting a pathway of human T cell differentiation characterized by changes in the expression of CCR7, CD28, CD27 and CD62L, few studies have addressed the mechanisms of pathway regulation. Cutaneous lymphocyte-associated antigen (CLA)-positive skin-homing CD8(+) T cells expressed significantly elevated levels of activation markers compared with CLA(-) CD8(+) T cells in individuals (n = 27) with cutaneous atopic disease. Despite such an activated phenotype, CLA(+) T cells expressed significantly higher levels of CCR7 than a CLA(-) T cell subset. Interleukin (IL)-4 was found to dramatically promote CCR7 expression by antigen-specific CD8(+) cells. Furthermore, skin-homing CD8(+) T cells from individuals with severe disease produced significantly less IL-10 than those derived from mildly affected atopic subjects. Thus in a T-helper 2 dominated disease, tissue-specific CD8(+) T cells show altered CCR7 expression and cytokine production, which may contribute to continued lymph node homing, antigen presentation and disease. IL-4 promotes expression of CCR7, a marker linked to existing models of CD8(+) T cell differentiation.
机译：尽管有强有力的证据支持以CCR7，CD28，CD27和CD62L表达变化为特征的人类T细胞分化途径，但很少有研究探讨途径调节的机制。与患有皮肤异位性疾病的个体（n = 27）相比，皮肤淋巴细胞相关抗原（CLA）阳性的皮肤归巢CD8（+）T细胞表达的活化标志物水平明显高于CLA（-）CD8（+）T细胞。尽管具有这种激活的表型，但CLA（+）T细胞表达的CCR7水平明显高于CLA（-）T细胞子集。发现白介素（IL）-4可通过抗原特异性CD8（+）细胞显着促进CCR7表达。此外，患有严重疾病的人的皮肤归巢的CD8（+）T细胞产生的IL-10明显少于受轻度过敏的受试者的IL-10。因此，在以T辅助2为主的疾病中，组织特异性CD8（+）T细胞显示出CCR7表达和细胞因子产生改变，这可能有助于持续的淋巴结归巢，抗原呈递和疾病。 IL-4促进CCR7的表达，CCR7是与CD8（+）T细胞分化的现有模型相关的标记。

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