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首页> 外文期刊>European journal of pharmaceutical sciences >Microdialysis--theoretical background and recent implementation in applied life-sciences.
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Microdialysis--theoretical background and recent implementation in applied life-sciences.

机译：微透析-应用生命科学的理论背景和最新实施。

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摘要

In the past decade microdialysis has become a method of choice in the study of unbound tissue concentrations of both endogenous and exogenous substances. Microdialysis has been shown to offer information about substances directly at the site of action while being well tolerable and safe. The large variety of its field of application has been demonstrated. However, a few challenges have to be met to make this method generally applicable in routine applications. This review will provide an overview over theoretical aspects that have to be considered during the implementation of microdialysis. Moreover, a comparison between microdialysis and other tissue sampling techniques will demonstrate advantages and limitations of the methods mentioned. Subsequently, it will present a critical synopsis of a variety of scientific/biomedical applications of this method with emphasis on the most recent literature, focussing on target tissues while giving examples of substances examined. It is concluded that microdialysis will be of great value in future investigations of pharmacokinetics, pharmacodynamics and in monitoring of disease status and progression.
机译：在过去的十年中，微透析已成为研究内源性和外源性物质的未结合组织浓度的一种选择方法。微透析已被证明可以直接在作用部位提供有关物质的信息，同时具有良好的耐受性和安全性。已经证明了其广泛的应用领域。但是，要使该方法普遍适用于常规应用，必须解决一些挑战。这篇综述将概述在微透析实施过程中必须考虑的理论方面。此外，微透析和其他组织采样技术之间的比较将证明上述方法的优点和局限性。随后，它将介绍该方法在各种科学/生物医学应用中的重要概要，重点放在最新文献上，着重于目标组织，同时给出所检查物质的示例。结论是，微透析将在未来的药代动力学，药效学研究以及疾病状况和进展的监测中具有重要的价值。

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