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首页> 外文期刊>European Journal of Pharmacology: An International Journal >Vasomotor action of insulin on the rabbit normal cavernous smooth muscle.
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Vasomotor action of insulin on the rabbit normal cavernous smooth muscle.

机译：胰岛素对兔正常海绵状平滑肌的血管舒张作用。

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摘要

Investigations on the effects of insulin on the normal vasculature have produced conflicting results. This study was aimed at establishing the vasomotor actions of insulin on normal cavernous smooth muscle. Insulin produced dose-dependent (10(-10)-10(-5) M) relaxation of the norepinephrine-precontracted strips of cavernosum, and of Bay K8644 [methyl-1,4-dihydro-2,6-dimethyl-3-nitro-4-2(trifluoromethylphenyl)pyridin e-5-carboxylate]-precontracted strips. Endothelial denudation or indomethacin (10 microM) pre-treatment significantly reduced these insulin-induced relaxations, whereas NG-nitro-L-arginine methyl ester (L-NAME, 5 mM) did not. Moreover, the pre-treatment of the cavernosum strips with a prostacyclin synthesis inhibitor [9,11-diazo-15-deoxy-prostaglandin H2 (U-51605), 10 microM] significantly reduced insulin-induced response, whereas pretreatment with a cyclooxygenase-2 (COX-2) inhibitor (NS-398, 10 microM) did not. In addition, responses to insulin were not inhibited by K+ channel blockers, i.e., tetraethylammonium (TEA, 10 mM) or 4-aminopyridine (4-AP, 10 microM). Moreover, L-type Ca2+ currents were reduced by prostacyclin (2 microM) but not by insulin (10 microM). We conclude that insulin induces the endothelium-dependent relaxation of cavernous smooth muscles and that this relaxation response may emanate from the direct inhibition of L-type Ca2+ channels by prostacyclin.
机译：关于胰岛素对正常脉管系统作用的研究产生了矛盾的结果。这项研究旨在确定胰岛素对正常海绵状平滑肌的血管舒缩作用。胰岛素产生去甲肾上腺素预先收缩的海绵状海绵体和Bay K8644 [甲基-1,4-二氢-2,6-二甲基-3-甲基]的剂量依赖性（10（-10）-10（-5）M）弛豫。硝基-4-2（三氟甲基苯基）吡啶鎓e-5-羧酸盐]预缩条。内皮剥脱术或消炎痛（10 microM）预处理显着降低了这些胰岛素诱导的松弛，而NG-硝基-L-精氨酸甲酯（L-NAME，5 mM）则没有。此外，用前列环素合成抑制剂[9,11-重氮-15-脱氧-前列腺素H2（U-51605），10 microM]预处理海绵体带可显着降低胰岛素诱导的反应，而用环氧合酶-酶预处理2（COX-2）抑制剂（NS-398，10 microM）没有。此外，K +通道阻滞剂即四乙铵（TEA，10 mM）或4-氨基吡啶（4-AP，10 microM）不会抑制对胰岛素的反应。此外，前列环素（2 microM）降低了L型Ca2 +电流，但胰岛素（10 microM）没有降低。我们得出结论，胰岛素诱导海绵状平滑肌的内皮依赖性舒张，并且这种舒张反应可能源于前列环素对L型Ca2 +通道的直接抑制。

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