Re: Phase III study of molecularly targeted adjuvant therapy in locally advanced urothelial cancer of the bladder based on p53 status

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Re: Phase III study of molecularly targeted adjuvant therapy in locally advanced urothelial cancer of the bladder based on p53 status

机译：回复：基于p53状态的分子靶向辅助治疗在局部晚期膀胱尿路上皮癌中的III期研究

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Conventional prognostic indicators for bladder cancer, such as tumor grade, stage, size, variant histopathology, and multi-focality, incompletely predict clinical outcome. This trial represents the largest randomized study of adjuvant chemotherapy for bladder cancer and the first study to use methotrexate, vinblastine, doxorubicin, and cisplatin (MVAC) based on p53 genetic alteration. This study analyzed 499 patients with T1-T2N0 bladder cancer who had undergone radical cystec-tomy and pelvic lymph node dissection for p53 expression by immunohistochemistry. Subjects with altered p53 expression were then randomly assigned to three cycles of MVAC versus observation.

机译：膀胱癌的常规预后指标，例如肿瘤等级，分期，大小，组织病理学变异和多灶性，不能完全预测临床结果。该试验是针对膀胱癌的辅助化疗最大的随机研究，也是基于p53基因改变使用甲氨蝶呤，长春碱，阿霉素和顺铂（MVAC）的第一项研究。这项研究通过免疫组化分析了499例T1-T2N0膀胱癌患者，这些患者经过根治性膀胱切开术和盆腔淋巴结清扫术后p53的表达。然后将具有改变的p53表达的受试者随机分配至三个周期的MVAC对比观察。

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《European urology》 |2012年第5期|共2页
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中图分类泌尿科学（泌尿生殖系疾病）;
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1. Re: Phase III study of molecularly targeted adjuvant therapy in locally advanced urothelial cancer of the bladder based on p53 status [J] . FlaigT.W., TheodorescuD. European urology . 2012,第1期

机译：回复：基于p53状态的分子靶向辅助治疗在局部晚期膀胱尿路上皮癌中的III期研究
2. Re: Phase III study of molecularly targeted adjuvant therapy in locally advanced urothelial cancer of the bladder based on p53 status [J] . WoodD.P. The Journal of Urology . 2012,第6期

机译：回复：基于p53状态的分子靶向辅助治疗在局部晚期膀胱尿路上皮癌中的III期研究
3. Phase III study of molecularly targeted adjuvant therapy in locally advanced urothelial cancer of the bladder based on p53 status. [J] . Stadler WM, Lerner SP, Groshen S, Journal of Clinical Oncology . 2011,第25期

机译：基于p53状态的局部靶向膀胱尿路上皮癌分子靶向辅助治疗的III期研究。
4. Adjuvant Neutron Therapy in Complex Treatment of Patients with Locally Advanced Breast Cancer [C] . V. A. Lisin, V. V. Velikaya, Zh. A. Startseva, International Conference on Physics of Cancer : Interdisciplinary Problems and Clinical Applications . 2017

机译：佐剂中子治疗复杂治疗局部晚期乳腺癌患者
5. Treatment patterns, costs and outcomes of systemic chemotherapy, adjuvant intravesical therapy, and surveillance for urothelial bladder cancer. [D] . Kerrigan, Matthew Charles. 2007

机译：全身化疗，辅助膀胱内治疗和尿路上皮膀胱癌监测的治疗方式，费用和结果。
6. Phase III Study of Molecularly Targeted Adjuvant Therapy in Locally Advanced Urothelial Cancer of the Bladder Based on p53 Status [O] . Walter M. Stadler, Seth P. Lerner, Susan Groshen, -1

机译：基于p53状态的局部晚期膀胱癌分子靶向辅助治疗的III期研究
7. Re: Phase III Study of Molecularly Targeted Adjuvant Therapy in Locally Advanced Urothelial Cancer of the Bladder Based on p53 Status [O] . Thomas W. Flaig, Dan Theodorescu 2012

机译：RE：基于P53状态的膀胱局部晚期尿路上皮癌分子靶向辅助治疗的第III期研究

Re: Phase III study of molecularly targeted adjuvant therapy in locally advanced urothelial cancer of the bladder based on p53 status

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